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Academic Journal

4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates.

  • Authors : Hirata K; Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.; Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Izumi, Osaka, 594-1101, Japan.

Subjects: Apoptosis/Apoptosis/Apoptosis/*drug effects ; Down Syndrome/Down Syndrome/Down Syndrome/*pathology ; Neurons/Neurons/Neurons/*drug effects

  • Source: Scientific reports [Sci Rep] 2020 Aug 20; Vol. 10 (1), pp. 14047. Date of Electronic Publication: 2020 Aug 20.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype.

  • Authors : Tramutola A; Department of Biochemical Sciences, Sapienza University of Rome, Italy.; Pupo G

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Apoptosis/Apoptosis/Apoptosis/*physiology ; Down Syndrome/Down Syndrome/Down Syndrome/*metabolism

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2016; Vol. 52 (1), pp. 359-371.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908

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Academic Journal

Apoptosis in Down's syndrome: lessons from studies of human and mouse models.

  • Authors : Rueda N; Department of Physiology and Pharmacology, Faculty of Medicine University of Cantabria, 39011 Santander, Spain.; Flórez J

Subjects: Apoptosis/Apoptosis/Apoptosis/*genetics ; Down Syndrome/Down Syndrome/Down Syndrome/*genetics ; Down Syndrome/Down Syndrome/Down Syndrome/*pathology

  • Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2013 Feb; Vol. 18 (2), pp. 121-34.Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Print Cited Medium: Internet ISSN: 1573-675X

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Academic Journal

Pulmonary epithelial apoptosis in fetal down syndrome: not higher than normal.

  • Authors : Bruijn M; Emma Children's Hospital/Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. ; von der Thüsen JH

Subjects: Apoptosis*; Down Syndrome/Down Syndrome/Down Syndrome/*pathology ; Epithelial Cells/Epithelial Cells/Epithelial Cells/*pathology

  • Source: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2012 May-Jun; Vol. 15 (3), Publisher: SAGE Publishing Country of Publication: United States NLM ID: 9809673 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Academic Journal

Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.

  • Authors : Sun X; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, Graduate Program in Neuroscience, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.; Wu Y

Subjects: Apoptosis*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Caspase 3/Caspase 3/Caspase 3/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2011 Mar 18; Vol. 286 (11), pp. 9049-62. Date of Electronic Publication: 2011 Jan 07.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

T lymphocytes apoptosis and mitochondrial membrane potential in Down's syndrome.

Subjects: Apoptosis*; Down Syndrome/Down Syndrome/Down Syndrome/*physiopathology ; Membrane Potential, Mitochondrial/Membrane Potential, Mitochondrial/Membrane Potential, Mitochondrial/*physiology

  • Source: Fetal and pediatric pathology [Fetal Pediatr Pathol] 2011; Vol. 30 (1), pp. 45-52.Publisher: Informa Healthcare Country of Publication: England NLM ID: 101230972 Publication Model: Print Cited Medium: Internet ISSN: 1551-3823

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Academic Journal

Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.

  • Authors : Micali N; Laboratory of Molecular Dynamics of the Nucleus, Division of Genetics and Cell Biology, S. Raffaele Scientific Institute, via Olgettina 60, Milan, Italy.; Longobardi E

Subjects: Apoptosis*; Down Syndrome/Down Syndrome/Down Syndrome/*metabolism ; Homeodomain Proteins/Homeodomain Proteins/Homeodomain Proteins/*metabolism

  • Source: Nucleic acids research [Nucleic Acids Res] 2010 Jun; Vol. 38 (11), pp. 3595-604. Date of Electronic Publication: 2010 Jan 27.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis.

  • Authors : Busciglio J; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA. ; Pelsman A

Subjects: Apoptosis/Apoptosis/Apoptosis/*physiology ; Down Syndrome/Down Syndrome/Down Syndrome/*metabolism ; Neurons/Neurons/Neurons/*metabolism

  • Source: Current pharmaceutical design [Curr Pharm Des] 2007; Vol. 13 (11), pp. 1091-8.Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9602487 Publication Model: Print Cited Medium: Internet

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Academic Journal

Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7.

  • Authors : Wu Y; Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders and Ministry of Education Key Lab of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, Vancouver, British Columbia, Canada.

Subjects: Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*physiology ; Apoptosis/Apoptosis/Apoptosis/*genetics ; Down-Regulation/Down-Regulation/Down-Regulation/*genetics

  • Source: Neurobiology of aging [Neurobiol Aging] 2015 Jan; Vol. 36 (1), pp. 169-77. Date of Electronic Publication: 2014 Aug 07.Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Assessing apoptosis gene expression profiling with a PCR array in the hippocampus of Ts65Dn mice.

  • Authors : Yu B; Changzhou Woman and Children Health Hospital Affiliated to Nanjing Medical University, No. 26 Bo Ai Road, Changzhou, Jiangsu 213003, Jiangsu Province, China.; Zhang B

Subjects: Apoptosis/Apoptosis/Apoptosis/*genetics ; Down Syndrome/Down Syndrome/Down Syndrome/*genetics ; Down Syndrome/Down Syndrome/Down Syndrome/*pathology

  • Source: BioMed research international [Biomed Res Int] 2015; Vol. 2015, pp. 214618. Date of Electronic Publication: 2015 May 05.Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  117 results for ""DOWN syndrome""