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Agricola

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Phase Ib adaptive study of dasatinib for the prevention of oxaliplatin-induced neuropathy in patients with gastrointestinal (GI) cancers receiving FOLFOX chemotherapy with or without bevacizumab.

• Authors : Noonan, Anne M.; Schnell, Patrick; Trunzo, Danielle

• Source: Journal of Clinical Oncology; 2024 Supplement 3, Vol. 42, p745-745, 42p

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Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice

• Authors : Huang, Kevin M.; Leblanc, Alix F.; Uddin, Muhammad Erfan

• Source: Journal of Clinical Investigation. September, 2020, Vol. 130 Issue 9, p4601, 6 p.

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Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice

• Authors : Li, Yang; Kazuki, Yasuhiro; Drabison, Thomas

• Source: Drug Metabolism and Disposition; 2024, Vol. 52 Issue: 2 p80-85, 6p

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Agricola

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OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity

• Authors : Leblanc, Alix F.; Sprowl, Jason A.; Alberti, Paola

• Source: Journal of Clinical Investigation. February, 2018, Vol. 128 Issue 2, p816, 10 p.

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Agricola

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Itraconazole-Induced Increases in Gilteritinib Exposure Are Mediated by CYP3A and OATP1B.

• Authors : Garrison, Dominique A.; Jin, Yan; Talebi, Zahra

Subjects: BORTEZOMIB; CYTOCHROME P-450 CYP3A; PROTEIN-tyrosine kinase inhibitors

• Source: Molecules; Oct2022, Vol. 27 Issue 20, p6815-N.PAG, 14p

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Transporters and Toxicity: Insights From the International Transporter Consortium Workshop 4.

• Authors : Hafey, Michael J.; Aleksunes, Lauren M.; Bridges, Christy C.

Subjects: CONSORTIA; MEMBRANE transport proteins; ORGANISTS

• Source: Clinical Pharmacology & Therapeutics; Sep2022, Vol. 112 Issue 3, p527-539, 13p

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Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium.

• Authors : Brouwer, Kim L.R.; Evers, Raymond; Hayden, Elizabeth

Subjects: CARRIER proteins; PROTEIN transport; MEMBRANE transport proteins

• Source: Clinical Pharmacology & Therapeutics; Sep2022, Vol. 112 Issue 3, p461-484, 24p

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