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Academic Journal

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.

  • Authors : Alteen MG; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; POINT Biopharma, 22 St Clair Avenue E Suite 1201, Toronto, ON M4T 2S3, Canada.

Subjects: Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/chemistry ; Nuclear Proteins*/Nuclear Proteins*/Nuclear Proteins*/chemistry; Cryoelectron Microscopy

  • Source: Structure (London, England : 1993) [Structure] 2023 Sep 07; Vol. 31 (9), pp. 1121-1131.e6. Date of Electronic Publication: 2023 Jun 29.Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues.

  • Authors : Hoschek F; Department of Neurology, University Hospital Ulm, 89081, Ulm, Germany.; Natan J

Subjects: Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/genetics ; Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/metabolism ; Huntington Disease*/Huntington Disease*/Huntington Disease*/genetics

  • Source: Molecular medicine (Cambridge, Mass.) [Mol Med] 2024 Mar 08; Vol. 30 (1), pp. 36. Date of Electronic Publication: 2024 Mar 08.Publisher: BioMed Central Country of Publication: England NLM ID: 9501023 Publication Model: Electronic Cited Medium: Internet ISSN: 1528-3658

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Academic Journal

The HSPB1-p62/SQSTM1 functional complex regulates the unconventional secretion and transcellular spreading of the HD-associated mutant huntingtin protein.

  • Authors : Bonavita R; Department of Molecular Medicine and Medical Biotechnologies, University of Naples 'Federico II', 80131 Naples, Italy.; Scerra G

Subjects: Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/metabolism ; Huntington Disease*/Huntington Disease*/Huntington Disease*/metabolism ; Phosphatidylinositol 3-Kinases*/Phosphatidylinositol 3-Kinases*/Phosphatidylinositol 3-Kinases*/genetics

  • Source: Human molecular genetics [Hum Mol Genet] 2023 Jul 04; Vol. 32 (14), pp. 2269-2291.Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1.

  • Authors : Pandey NK; Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Varkey J

Subjects: Artifacts* ; Exons*/Exons*/Exons*/genetics ; Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/chemistry

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Jan; Vol. 300 (1), pp. 105585. Date of Electronic Publication: 2023 Dec 21.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Interaction between huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins.

  • Authors : Zhang H; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.; University of the Chinese Academy of Sciences, Beijing, China.

Subjects: Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/genetics ; Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/chemistry ; Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/metabolism

  • Source: Protein science : a publication of the Protein Society [Protein Sci] 2023 Dec; Vol. 32 (12), Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet

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Academic Journal

Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide.

  • Authors : Song H; Neurology Department at Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, School of Life Sciences, Fudan University, Shanghai 200438, China.; Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, Guangdong 511458, China.

Subjects: Desonide*/Desonide*/Desonide*/chemistry ; Desonide*/Desonide*/Desonide*/pharmacology ; Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/chemistry

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Mar 08; Vol. 119 (10), pp. e2114303119. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Glyceraldehyde-3-Phosphate Dehydrogenase Facilitates Macroautophagic Degradation of Mutant Huntingtin Protein Aggregates.

  • Authors : Chaudhary S; Institute of Microbial Technology, CSIR, Sector 39A, Chandigarh, India, 160036.; Dhiman A

Subjects: Protein Aggregates*; Autophagy/Autophagy/Autophagy/*physiology ; Glyceraldehyde-3-Phosphate Dehydrogenases/Glyceraldehyde-3-Phosphate Dehydrogenases/Glyceraldehyde-3-Phosphate Dehydrogenases/*physiology

  • Source: Molecular neurobiology [Mol Neurobiol] 2021 Nov; Vol. 58 (11), pp. 5790-5798. Date of Electronic Publication: 2021 Aug 18.Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Molecular basis of Q-length selectivity for the MW1 antibody-huntingtin interaction.

  • Authors : Bravo-Arredondo JM; Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.; Venkataraman R

Subjects: Antibodies, Monoclonal*/Antibodies, Monoclonal*/Antibodies, Monoclonal*/metabolism ; Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/chemistry ; Huntingtin Protein*/Huntingtin Protein*/Huntingtin Protein*/genetics

  • Source: The Journal of biological chemistry [J Biol Chem] 2023 Apr; Vol. 299 (4), pp. 104616. Date of Electronic Publication: 2023 Mar 16.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Pan-neuronal expression of human mutant huntingtin protein in Drosophila impairs immune response of hemocytes.

  • Authors : Dhankhar J; Department of Zoology, University of Delhi, New Delhi 110007, India.; Agrawal N

Subjects: Hemocytes/Hemocytes/Hemocytes/*immunology ; Huntingtin Protein/Huntingtin Protein/Huntingtin Protein/*genetics ; Huntington Disease/Huntington Disease/Huntington Disease/*immunology

  • Source: Journal of neuroimmunology [J Neuroimmunol] 2022 Feb 15; Vol. 363, pp. 577801. Date of Electronic Publication: 2021 Dec 25.Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Generation of induced pluripotent stem cells from three individuals with Huntington's disease.

  • Authors : Miller DC; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.

Subjects: Huntington Disease*/Huntington Disease*/Huntington Disease*/genetics ; Huntington Disease*/Huntington Disease*/Huntington Disease*/pathology ; Induced Pluripotent Stem Cells*/Induced Pluripotent Stem Cells*/Induced Pluripotent Stem Cells*/pathology

  • Source: Stem cell research [Stem Cell Res] 2022 Dec; Vol. 65, pp. 102976. Date of Electronic Publication: 2022 Nov 17.Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753

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  • 1-10 of  17,980 results for ""Huntingtin Protein""