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Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration.

• Authors : Kim TH; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea.; Yang YM

Subjects: Oxygen Consumption* ; Signal Transduction*; Endopeptidases/Endopeptidases/Endopeptidases/*metabolism

• Source: The Journal of clinical investigation [J Clin Invest] 2018 Dec 03; Vol. 128 (12), pp. 5587-5602. Date of Electronic Publication: 2018 Nov 12.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited

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Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism.

• Authors : Koo JH; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea.; Kim TH

Subjects: Energy Metabolism*; Fatty Liver/Fatty Liver/Fatty Liver/*metabolism ; GTP-Binding Protein alpha Subunits, G12-G13/GTP-Binding Protein alpha Subunits, G12-G13/GTP-Binding Protein alpha Subunits, G12-G13/*metabolism

• Source: The Journal of clinical investigation [J Clin Invest] 2017 Oct 02; Vol. 127 (10), pp. 3845-3860. Date of Electronic Publication: 2017 Sep 18.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited

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Agricola

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Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes.

• Authors : Kim, Ayoung; Koo, Ja Hyun; Jin, Xing

Subjects: DEUBIQUITINATING enzymes; SKELETAL muscle; TYPE 2 diabetes

• Source: Journal of Cachexia, Sarcopenia & Muscle; Dec2021, Vol. 12 Issue 6, p1669-1689, 21p

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Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration.

• Authors : Tae Hyun Kim; Yoon Mee Yang; Chang Yeob Han

Subjects: OBESITY; LIVER diseases; MITOCHONDRIA

• Source: Journal of Clinical Investigation. Dec2018, Vol. 128 Issue 12, p5587-5602. 16p. 1 Diagram, 1 Chart, 7 Graphs.

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