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Academic Journal

Structure-guided design of potent JAK1-selective inhibitors based on 4-amino-7H-pyrrolo[2,3-d]pyrimidine with anti-inflammatory efficacy.

  • Authors : Zhang J; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.; Xing S

Subjects: Pyrimidines*/Pyrimidines*/Pyrimidines*/pharmacology ; Pyrimidines*/Pyrimidines*/Pyrimidines*/chemistry ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/pharmacology

  • Source: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Apr; Vol. 357 (4), pp. e2300591. Date of Electronic Publication: 2024 Jan 07.Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Epigenetic-based combination therapy and liposomal codelivery overcomes osimertinib-resistant NSCLC via repolarizing tumor-associated macrophages.

  • Authors : Lin TT; Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, 256603, China.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Subjects: Acrylamides*/Acrylamides*/Acrylamides*/pharmacology ; Acrylamides*/Acrylamides*/Acrylamides*/therapeutic use ; Aniline Compounds*/Aniline Compounds*/Aniline Compounds*/pharmacology

  • Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2024 Apr; Vol. 45 (4), pp. 867-878. Date of Electronic Publication: 2023 Dec 19.Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Computer aided drug discovery (CADD) of a thieno[2,3- d ]pyrimidine derivative as a new EGFR inhibitor targeting the ribose pocket.

  • Authors : Sobh EA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Shibin-Elkom, Menoufia, Egypt.; Dahab MA

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry ; ErbB Receptors*/ErbB Receptors*/ErbB Receptors*/antagonists & inhibitors ; Pyrimidines*/Pyrimidines*/Pyrimidines*/pharmacology

  • Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Mar; Vol. 42 (5), pp. 2369-2391. Date of Electronic Publication: 2023 May 02.Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

GSK-3β inhibitor TWS119 promotes neuronal differentiation after hypoxic-ischemic brain damage in neonatal rats.

  • Authors : Gao L; Departments of Neonatology.; Gao S

Subjects: Hypoxia-Ischemia, Brain*/Hypoxia-Ischemia, Brain*/Hypoxia-Ischemia, Brain*/drug therapy ; Pyrimidines*/Pyrimidines*/Pyrimidines*/pharmacology ; Pyrimidines*/Pyrimidines*/Pyrimidines*/therapeutic use

  • Source: Neuroreport [Neuroreport] 2024 Feb 07; Vol. 35 (3), pp. 200-207. Date of Electronic Publication: 2024 Jan 31.Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100935 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Sialyltransferase ST3GAL4 confers osimertinib resistance and offers strategies to overcome resistance in non-small cell lung cancer.

  • Authors : Han R; Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, China.; Lin C

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/drug therapy ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/genetics ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/drug therapy

  • Source: Cancer letters [Cancer Lett] 2024 Apr 28; Vol. 588, pp. 216762. Date of Electronic Publication: 2024 Feb 24.Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Endocrine and Targeted Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer-Capivasertib-Fulvestrant: ASCO Rapid Recommendation Update.

Subjects: Breast Neoplasms*/Breast Neoplasms*/Breast Neoplasms*/drug therapy ; Pyrimidines* ; Pyrroles*

  • Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2024 Apr 20; Vol. 42 (12), pp. 1450-1453. Date of Electronic Publication: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Overall Survival From the EORTC LCG-1613 APPLE Trial of Osimertinib Versus Gefitinib Followed by Osimertinib in Advanced EGFR -Mutant Non-Small-Cell Lung Cancer.

  • Authors : Remon J; Paris-Saclay University, Institut Gustave Roussy, Villejuif, France.; Besse B

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/drug therapy ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/drug therapy ; Acrylamides*

  • Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2024 Apr 20; Vol. 42 (12), pp. 1350-1356. Date of Electronic Publication: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

DB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors.

  • Authors : Li X; Department of Research and Development, Duality Biologics, LTD, Unite 1106 868 Yinghua Road, Shanghai, 201204, P.R. China. .; Yao J

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/pathology ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/drug therapy ; Immunoconjugates*/Immunoconjugates*/Immunoconjugates*/pharmacology

  • Source: Journal of translational medicine [J Transl Med] 2024 Apr 17; Vol. 22 (1), pp. 362. Date of Electronic Publication: 2024 Apr 17.Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876

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Academic Journal

Vericiguat suppresses ventricular tachyarrhythmias inducibility in a rabbit myocardial infarction model.

  • Authors : Chang PC; Department of Internal Medicine, Division of Cardiology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.; Medical School, Chang Gung University, Taoyuan, Taiwan.

Subjects: Myocardial Infarction*/Myocardial Infarction*/Myocardial Infarction*/complications ; Myocardial Infarction*/Myocardial Infarction*/Myocardial Infarction*/drug therapy ; Tachycardia, Ventricular*/Tachycardia, Ventricular*/Tachycardia, Ventricular*/drug therapy

  • Source: PloS one [PLoS One] 2024 Apr 16; Vol. 19 (4), pp. e0301970. Date of Electronic Publication: 2024 Apr 16 (Print Publication: 2024).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

CYP7A1 Gene Induction via SHP-Dependent or Independent Mechanisms can Increase the Risk of Drug-Induced Liver Injury Independently or in Synergy with BSEP Inhibition.

  • Authors : Niu C; Drug Metabolism, Gilead Sciences Inc., Foster City, California.; Xie X

Subjects: Indazoles* ; Chemical and Drug Induced Liver Injury*/Chemical and Drug Induced Liver Injury*/Chemical and Drug Induced Liver Injury*/genetics ; Pyrimidines*

  • Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Apr 16; Vol. 52 (5), pp. 432-441. Date of Electronic Publication: 2024 Apr 16.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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  • 1-10 of  80,127 results for ""PYRIMIDINES""