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Reports Outline Wolfram Syndrome Findings from Tongji University (Isr Inhibition Reverses Pancreatic B-cell Failure In Wolfram Syndrome Models)

• Source: Obesity, Fitness & Wellness Week. March 9, 2024, 280

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Recent Research from Mahidol University Highlight Findings in Apoptosis (Imatinib Prevents Dexamethasone-induced Pancreatic B-cell Apoptosis Via Decreased Trail and Dr5)

• Source: Obesity, Fitness & Wellness Week. February 24, 2024, 169

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Volgograd State Medical University Researchers Report on Findings in Type 2 Diabetes (Pancreatic b-cell protective effect of novel GABA derivatives in rats with type 2 diabetes)

• Source: Obesity, Fitness & Wellness Week. February 3, 2024, p318.

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Affiliated Hospital of Zunyi Medical University Researchers Describe Findings in Diabetes Mellitus (Periodontitis promotes the progression of diabetes mellitus by enhancing autophagy)

• Source: Obesity, Fitness & Wellness Week. February 3, 2024, p21.

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Data on Obesity Described by a Researcher at State University of Campinas (UNICAMP) (Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing beta cell function and survival via FGF15/19)

• Source: Obesity, Fitness & Wellness Week. January 13, 2024, p99.

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Findings from Nihon University Reveals New Findings on Insulinoma (The Role of Carbonic Anhydrases In Glucose-stimulated Insulin Secretion From Insulinoma Min6 Cells)

• Source: Obesity, Fitness & Wellness Week. January 6, 2024, 2173

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Researchers from Shenyang Pharmaceutical University Discuss Findings in Life Science (Silibinin Alleviates Ferroptosis of Rat Islet & Beta; Cell Ins-1 Induced By the Treatment With Palmitic Acid and High Glucose Through Enhancing Pink1/ ...)

• Source: Obesity, Fitness & Wellness Week. August 5, 2023, p3710.

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Autoimmune gastritis as an unexpected cause of diarrhea in a young adult with type I diabetes: a case report

• Authors : Meyers, Taylor M.; Reeves, Patrick T.; Lombardo, Jamie L.

• Source: Journal of Medical Case Reports. July 29, 2023, Vol. 17 Issue 1

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DYRK1A inhibitors leucettines and TGF-[beta] inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets

• Authors : Pucelik, Barbara; Barzowska, Agata; Czarna, Anna

• Source: PLoS ONE. May 17, 2023, Vol. 18 Issue 5, e0285208

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RyR2 regulates store-operated Ca.sup.2+ entry, phospholipase C activity, and electrical excitability in the insulinoma cell line INS-1

• Authors : Harvey, Kyle E.; Tang, Shiqi; LaVigne, Emily K.

• Source: PLoS ONE. May 4, 2023, Vol. 18 Issue 5, e0285316

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Parkin-mediated mitophagy is negatively regulated by FOXO3A, which inhibits Plk3-mediated mitochondrial ROS generation in STZ diabetic stress-treated pancreatic [beta] cells

• Authors : Shim, Ji Yeon; Chung, Jin Ook; Jung, Dawa

• Source: PLoS ONE. May 3, 2023, Vol. 18 Issue 5, e0281496

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A New Berberine Preparation Protects Pancreatic Islet Cells from Apoptosis Mediated by Inhibition of Phospholipase [A.sub.2]/p38 MAPK Pathway

• Authors : Bi, X.J.; Lv, Y.Q.; Yang, X.H.

• Source: Bulletin of Experimental Biology and Medicine. July 2022, Vol. 173 Issue 3, p346, 8 p.

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Studies from Peking University Third Hospital Have Provided New Information about Glucose Elevating Agents (Glucagon Acting At the Glp-1 Receptor Contributes To Beta-cell Regeneration Induced By Glucagon Receptor Antagonism In Diabetic Mice)

• Source: Obesity, Fitness & Wellness Week. July 22, 2023, 328

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Findings from School of Bioengineering Broaden Understanding of Diabetes Research (Dysfunctions, Molecular Mechanisms, and Therapeutic Strategies of Pancreatic Beta-cells In Diabetes)

• Source: Obesity, Fitness & Wellness Week. July 15, 2023, 88

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Findings from Yonsei University Update Knowledge of Type 2 Diabetes (?-hydroxybutyrate As a Biomarker of ?-cell Function In New-onset Type 2 Diabetes and Its Association With Treatment Response At 6 Months)

• Source: Obesity, Fitness & Wellness Week. July 8, 2023, 75

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Findings from University of Shizuoka Reveals New Findings on Proinsulin (Development of Therapeutic Agents With a Novel Mechanism of Action Targeting Pancreatic Beta-cells for Diabetes)

• Source: Obesity, Fitness & Wellness Week. July 8, 2023, 72

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New Study Findings from Instituto de Investigacion Biomedica de Malaga (IBIMA) Illuminate Research in Type 2 Diabetes (Higher b cell death in pregnant women, measured by DNA methylation patterns of cell-free DNA, compared to new-onset type 1 ...)

• Source: Obesity, Fitness & Wellness Week. June 24, 2023, 161

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New Type 2 Diabetes Findings Reported from Department of Internal Medicine (The Effects of Early Short-term Insulin Treatment Vs. Glimepiride On Beta Cell Function In Newly Diagnosed Type 2 Diabetes With Hba1c Above 9%)

• Source: Obesity, Fitness & Wellness Week. June 17, 2023, 201

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Reports Summarize Insulin Resistance Study Results from Xinjiang Uygur Autonomous Region People's Hospital (Txlng Improves Insulin Resistance In Obese Subjects In Vitro and In Vivo By Inhibiting Atf4 Transcriptional Activity)

• Source: Obesity, Fitness & Wellness Week. June 10, 2023, 194

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Studies from University of Sao Paulo in the Area of Obesity Described (Adiponectin Reverses Beta-cell Damage and Impaired Insulin Secretion Induced By Obesity)

• Source: Obesity, Fitness & Wellness Week. June 3, 2023, 5994

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Findings from Chongqing University Yields New Data on Diabetes Mellitus (1,25d/vdr Inhibits Pancreatic Beta Cell Ferroptosis By Downregulating Foxo1 Expression In Diabetes Mellitus)

• Source: Obesity, Fitness & Wellness Week. May 6, 2023, 56

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Nutrient regulation of the islet epigenome controls adaptive insulin secretion

• Authors : Wortham, Matthew; Liu, Fenfen; Harrington, Austin R.

• Source: Journal of Clinical Investigation. April 15, 2023, Vol. 133 Issue 8

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Probiotics of Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 attenuate inflammation and [beta]-cell death in streptozotocin-induced type 1 diabetic mice

• Authors : Nopparat, Jongdee; Khuituan, Pissared; Peerakietkhajorn, Saranya

• Source: PLoS ONE. April 11, 2023, Vol. 18 Issue 4, e0284303

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Biomea Fusion Abstract "BMF-219: A Novel Therapeutic Agent to Reestablish Functional Beta Cells & Provide Long-term Glycemic Control" Selected as One of Six Oral Presentations at 21st World Congress Insulin Resistance, Diabetes & Cardiovascular Disease.

• Source: Plus Company Updates. 2023.

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Biomea Fusion Abstract "BMF-219: A Novel Therapeutic Agent to Reestablish Functional Beta Cells and Provide Long-term Glycemic Control" Selected as One of Six Oral Presentations at 21st World Congress Insulin Resistance, Diabetes & Cardiovascular Disease.

• Source: GlobeNewswire. 2023.

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Visceral Fat Accumulation Is Related to Impaired Pancreatic Blood Perfusion and Beta-Cell Dysfunction in Obese Women

• Authors : Szotkowská, Radka; Gojda, Jan; Plíhalová, Andrea

• Source: Annals of Nutrition and Metabolism. December 1, 2021, Vol. 77 Issue 6, p344, 6 p.

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A Review of Current Trends with Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments and Future Perspectives

• Authors : Reed, Josh; Bain, Stephen; Venkateswarlu

• Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. August 31, 2021, Vol. 14, p3567, 36 p.

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Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction

• Authors : Darenskaya, M.A.; Kolesnikova, L.I.; Kolesnikov, S.I.

• Source: Bulletin of Experimental Biology and Medicine. August 19, 2021, Vol. 171 Issue 2, p179, 11 p.

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Integration of ER protein quality control mechanisms defines [beta] cell function and ER architecture

• Authors : Shrestha, Neha; Torres, Mauricio; Zhang, Jason

• Source: Journal of Clinical Investigation. January, 2023, Vol. 133 Issue 1

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Recent Findings from Taipei Medical University Provides New Insights into Proinsulin (Pharmacological and Mechanistic Study of Ps1, a Pdia4 Inhibitor, In Beta-cell Pathogenesis and Diabetes In Db/db Mice)

• Source: Obesity, Fitness & Wellness Week. April 29, 2023, 116

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New Type 2 Diabetes Study Results Reported from Cardiovascular Research Institute (A Beta Cell Subset With Enhanced Insulin Secretion and Glucose Metabolism Is Reduced In Type 2 Diabetes)

• Source: Obesity, Fitness & Wellness Week. April 22, 2023, 164

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Findings from Ain Shams University Update Understanding of Type 2 Diabetes (Expression Silencing of Mitogen-activated Protein Kinase 8 Interacting Protein-1 Conferred Its Role In Pancreatic Beta-cell Physiology and Insulin Secretion)

• Source: Obesity, Fitness & Wellness Week. April 15, 2023, 73

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Studies from Southeast University Describe New Findings in Diabetes Research (Long-term Exercise Preserves Pancreatic Islet Structure and Beta-cell Mass Through Attenuation of Islet Inflammation and Fibrosis)

• Source: Obesity, Fitness & Wellness Week. April 1, 2023, 288

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New Proinsulin Study Findings Recently Were Reported by Researchers at Zhejiang University of Technology (Regeneration of Pancreatic Beta-cells for Diabetes Therapeutics By Natural Dyrk1a Inhibitors)

• Source: Obesity, Fitness & Wellness Week. March 25, 2023, 155

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Studies from Shanxi Medical University Have Provided New Data on Membrane Transport Proteins (Vpac2 Receptor Mediates Vip-potentiated Insulin Secretion Via Ion Channels In Rat Pancreatic Beta Cells)

• Source: Obesity, Fitness & Wellness Week. March 18, 2023, 5405

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Reports Summarize miRNA-Based Therapy Study Results from Jining Medical University (Immune Cell-derived Extracellular Vesicular Micrornas Induce Pancreatic Beta Cell Apoptosis)

• Source: Obesity, Fitness & Wellness Week. February 18, 2023, 353

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New Findings from Uppsala University Describe Advances in Apoptosis (Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine)

• Source: Obesity, Fitness & Wellness Week. February 11, 2023, 3288

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Researchers at Beckman Research Institute at the City of Hope Have Reported New Data on Proinsulin (Doc2b Enhances Beta-cell Function Via a Novel Tyrosine Phosphorylation-dependent Mechanism)

• Source: Obesity, Fitness & Wellness Week. February 11, 2023, 5388

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New Proinsulin Findings from Ministry of Education Described (Fufang-zhenzhu-tiaozhi Formula Protects Islet Against Injury and Promotes Beta Cell Regeneration In Diabetic Mice)

• Source: Obesity, Fitness & Wellness Week. February 4, 2023, 127

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Antiviral Meds Could Help Ease or Prevent Type 1 Diabetes in Kids, Study Finds.

• Authors : Mundell, Ernie

• Source: Consumer Health News (English). 2023.

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A novel angle on type 1 diabetes: RNA editing disruption mimics early-stage disease with no involvement of virus

• Source: NewsRx Health. January 14, 2024, p11.

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Altered microvasculature in pancreatic islets from subjects with type 1 diabetes

• Authors : Granlund, Louise; Hedin, Anders; Korsgren, Olle

• Source: PLoS ONE. October 31, 2022, Vol. 17 Issue 10, e0276942

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Effect of crude polysaccharide from seaweed, Dictyopteris divaricata (CDDP) on gut microbiota restoration and anti-diabetic activity in streptozotocin (STZ)-induced T1DM mice

• Authors : Siddiqui, Nimra Zafar; Rehman, Ata Ur; Yousuf, Waleed

• Source: Gut Pathogens. September 17, 2022, Vol. 14 Issue 1

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Stepwise differentiation of functional pancreatic [beta] cells from human pluripotent stem cells

• Authors : Jin, Wenwen; Jiang, Wei

• Source: Cell Regeneration. August 1, 2022, Vol. 11 Issue 1

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Antiviral Meds Could Help Ease or Prevent Type 1 Diabetes in Kids, Study Finds

• Source: Consumer Health News (English). October 4, 2023

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Investigators from Department of Endocrinology Zero in on Proinsulin (Study of Relationship Between Glucagon Level, Glycemic Status, and Beta-cell Function In Newly Diagnosed T2dm Patients, Treated With Insulin)

• Source: Obesity, Fitness & Wellness Week. January 28, 2023, 1571

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Studies from University of Paris in the Area of Type 2 Diabetes Reported (P2-type Purinergic Signaling In the Regulation of Pancreatic Beta-cell Functional Plasticity As a Promising Novel Therapeutic Approach for the Treatment of Type 2 ...)

• Source: Obesity, Fitness & Wellness Week. January 28, 2023, 283

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Researchers from University of Sao Paulo Describe Findings in Proinsulin (Citrus Flavanone Metabolites Protect Pancreatic Beta-cells Against Cholesterol Stress Through a Multi-proteomic Mechanism)

• Source: Obesity, Fitness & Wellness Week. January 21, 2023, 2611

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Human thymopoiesis produces polyspecific CD8.sup.+ [alpha]/[beta] T cells responding to multiple viral antigens.

• Authors : Quiniou, Valentin; Barennes, Pierre; Mhanna, Vanessa

• Source: eLife. March 30, 2023, Vol. 12.

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Gs/Gq signaling switch in [beta] cells defines incretin effectiveness in diabetes

• Authors : Oduori, Okechi S.; Murao, Naoya; Shimomura, Kenju

• Source: Journal of Clinical Investigation. December, 2020, Vol. 130 Issue 12, p6639, 17 p.

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