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Comprehensive functional characterization of a novel ANO6 variant in a new patient with Scott syndrome.

• Authors : Montague SJ; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.; Price J

• Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2024 Mar 15. Date of Electronic Publication: 2024 Mar 15.Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836

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Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1.

• Authors : Jooss NJ; Department of Biochemistry, Maastricht University, Maastricht, The Netherlands.; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Subjects: Integrin alpha2beta1*/Integrin alpha2beta1*/Integrin alpha2beta1*/genetics ; Thrombosis*/Thrombosis*/Thrombosis*/genetics; Humans

• Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 Jan 18; Vol. 81 (1), pp. 44. Date of Electronic Publication: 2024 Jan 18.Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071

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Platelet glycoprotein VI cluster size is related to thrombus formation and phosphatidylserine exposure in collagen-adherent platelets under arterial shear.

• Authors : Jooss NJ; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.

Subjects: Blood Platelets*/Blood Platelets*/Blood Platelets*/metabolism ; Thrombosis*; Humans

• Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2023 Aug; Vol. 21 (8), pp. 2260-2267. Date of Electronic Publication: 2023 May 05.Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836

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Pharmacological Inhibition of Glycoprotein VI- and Integrin α2β1-Induced Thrombus Formation Modulated by the Collagen Type.

• Authors : Jooss NJ; Department of Biochemistry, Cardiovascular Research Institute, Maastricht University, Maastricht, The Netherlands.; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

Subjects: Integrin alpha2beta1*/Integrin alpha2beta1*/Integrin alpha2beta1*/metabolism ; Thrombosis*/Thrombosis*/Thrombosis*/prevention & control; Humans

• Source: Thrombosis and haemostasis [Thromb Haemost] 2023 Jun; Vol. 123 (6), pp. 597-612. Date of Electronic Publication: 2023 Feb 17.Publisher: Thieme Country of Publication: Germany NLM ID: 7608063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2567-689X

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Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization.

• Authors : Damaskinaki FN; Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, The Midlands, UK

Subjects: Platelet Membrane Glycoproteins*/Platelet Membrane Glycoproteins*/Platelet Membrane Glycoproteins*/metabolism ; Collagen*/Collagen*/Collagen*/metabolism; Humans

• Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2023 Feb; Vol. 21 (2), pp. 317-328. Date of Electronic Publication: 2022 Dec 22.Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836

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S100A8/A9 drives the formation of procoagulant platelets through GPIbα.

• Authors : Colicchia M; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.; Schrottmaier WC

Subjects: Blood Platelets*/Blood Platelets*/Blood Platelets*/metabolism ; Calgranulin A*/Calgranulin A*/Calgranulin A*/metabolism ; COVID-19*/COVID-19*/COVID-19*/metabolism

• Source: Blood [Blood] 2022 Dec 15; Vol. 140 (24), pp. 2626-2643.Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020

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The Btk inhibitor AB-95-LH34 potently inhibits atherosclerotic plaque-induced thrombus formation and platelet procoagulant activity.

• Authors : Smith CW; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Harbi MH

Subjects: Plaque, Atherosclerotic*/Plaque, Atherosclerotic*/Plaque, Atherosclerotic*/complications ; Thrombosis*/Thrombosis*/Thrombosis*/drug therapy ; Atherosclerosis*/Atherosclerosis*/Atherosclerosis*/complications

• Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2022 Dec; Vol. 20 (12), pp. 2939-2952. Date of Electronic Publication: 2022 Oct 17.Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836

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CLEC-2 Supports Platelet Aggregation in Mouse but not Human Blood at Arterial Shear.

• Authors : Bourne JH; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.; Smith CW

Subjects: Plaque, Atherosclerotic* ; Thrombosis*; Mice

• Source: Thrombosis and haemostasis [Thromb Haemost] 2022 Dec; Vol. 122 (12), pp. 1988-2000. Date of Electronic Publication: 2022 Jul 11.Publisher: Thieme Country of Publication: Germany NLM ID: 7608063 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2567-689X

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Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins.

• Authors : Maqsood Z; Institute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.; Alacris Theranostics, GmbH, Berlin, Germany.

Subjects: src Homology Domains* ; Platelet Membrane Glycoproteins*; Computer Simulation

• Source: PLoS computational biology [PLoS Comput Biol] 2022 Nov 28; Vol. 18 (11), pp. e1010708. Date of Electronic Publication: 2022 Nov 28 (Print Publication: 2022).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet

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Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling, and thrombus formation.

• Authors : Jooss NJ; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.

Subjects: Plaque, Atherosclerotic* ; Single-Domain Antibodies*/Single-Domain Antibodies*/Single-Domain Antibodies*/pharmacology ; Thrombosis*

• Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2022 Nov; Vol. 20 (11), pp. 2617-2631. Date of Electronic Publication: 2022 Aug 12.Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836

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