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Academic Journal

BCL-X L inhibitors enhance the apoptotic efficacy of BRAF inhibitors in BRAF V600E colorectal cancer.

  • Authors : Jenkins LJ; Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia.; School of Cancer Medicine, La Trobe University, Melbourne, VIC, Australia.

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/therapeutic use ; bcl-X Protein*/bcl-X Protein*/bcl-X Protein*/antagonists & inhibitors

  • Source: Cell death & disease [Cell Death Dis] 2024 Mar 01; Vol. 15 (3), pp. 183. Date of Electronic Publication: 2024 Mar 01.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Profiling of the chemical space on the phenyl group of substituted benzothiazole RIPK3 inhibitors.

  • Authors : Xu Y; School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.; Liang C

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Benzothiazoles*/Benzothiazoles*/Benzothiazoles*/chemistry ; Benzothiazoles*/Benzothiazoles*/Benzothiazoles*/pharmacology

  • Source: Bioorganic chemistry [Bioorg Chem] 2023 Feb; Vol. 131, pp. 106339. Date of Electronic Publication: 2022 Dec 24.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors.

  • Authors : Abdallah AE; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.; Mabrouk RR

Subjects: Molecular Docking Simulation*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 573-591.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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Academic Journal

New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies.

  • Authors : Elkady H; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.; Elwan A

Subjects: Drug Design*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 397-410.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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Periodical

BMS buys Turning Point Therapeutics and its kinase inhibitors for $4.1 billion.

Subjects: Apoptosis* ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/pharmacology ; Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/Protein Kinase Inhibitors*/therapeutic use

  • Source: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2022 Jul; Vol. 21 (7), pp. 481.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print Cited Medium: Internet ISSN: 1474-1784

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Academic Journal

Design, synthesis and evaluation of anticancer activity of new pyrazoline derivatives by down-regulation of VEGF: Molecular docking and apoptosis inducing activity.

  • Authors : Hassan RA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.; Emam SH

Subjects: Drug Design* ; Molecular Docking Simulation*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology

  • Source: Bioorganic chemistry [Bioorg Chem] 2022 Jan; Vol. 118, pp. 105487. Date of Electronic Publication: 2021 Nov 13.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers.

  • Authors : Kassab AE; Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Cairo University, Cairo, Egypt.; Gedawy EM

Subjects: Drug Design*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 922-939.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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Academic Journal

Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3- a :3',4'- c ]quinoxaline derivatives as anticancer agents and apoptosis inducers.

  • Authors : Alsaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.; Taghour MS

Subjects: Drug Discovery*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects

  • Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 1093-1114.Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374

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Academic Journal

Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines.

  • Authors : Król SK; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Medical University of Lublin, Chodźki 1, 20-093 Lublin, Poland.; Bębenek E

Subjects: Apoptosis/Apoptosis/Apoptosis/*drug effects ; Cell Proliferation/Cell Proliferation/Cell Proliferation/*drug effects ; Extracellular Signal-Regulated MAP Kinases/Extracellular Signal-Regulated MAP Kinases/Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors

  • Source: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 14; Vol. 22 (22). Date of Electronic Publication: 2021 Nov 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

ZCL-082, a boron-containing compound, induces apoptosis of non-Hodgkin's lymphoma via targeting p90 ribosomal S6 kinase 1/NF-κB signaling pathway.

  • Authors : Ma C; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital / Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Department of Rehabilitation, Shanghai General Hospital, Shanghai Jiao Tong University, No. 100, Haining Road, Shanghai, 200080, China.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*therapeutic use ; Apoptosis/Apoptosis/Apoptosis/*drug effects ; Boron Compounds/Boron Compounds/Boron Compounds/*therapeutic use

  • Source: Chemico-biological interactions [Chem Biol Interact] 2022 Jan 05; Vol. 351, pp. 109770. Date of Electronic Publication: 2021 Nov 30.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786

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  • 1-10 of  3,212 results for ""Protein Kinase Inhibitors""