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Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis.

• Authors : Freeze, Robert; Yang, Kelly W.; Haystead, Timothy

Subjects: RHEUMATOID arthritis; TRANSFORMING growth factors-beta; ANTIRHEUMATIC agentsUNITED States. Food & Drug Administration

• Source: Pharmacology Research & Perspectives; Aug2023, Vol. 11 Issue 4, p1-11, 11p

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Transforming Growth Factor-β-Activated Kinase 1 (TAK1) Mediates Chronic Pain and Cytokine Production in Mouse Models of Inflammatory, Neuropathic, and Primary Pain

• Authors : Scarneo, Scott; Zhang, Xin; Wang, Yaomin

• Source: Journal of Pain; September 2023, Vol. 24 Issue: 9 p1633-1644, 12p

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Expression of membrane Hsp90 is a molecular signature of T cell activation.

• Authors : Scarneo, Scott A.; Smith, Aaron P.; Favret, Jacob

Subjects: INFLAMMATORY bowel diseases; HEAT shock proteins; RHEUMATOID arthritis

• Source: Scientific Reports; 10/27/2022, Vol. 12 Issue 1, p1-11, 11p

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Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain.

• Authors : Wang, Yaomin; Scarneo, Scott A.; Kim, Shin Hyung

• Source: PAIN; Jun2022, Vol. 163 Issue 6, p1091-1101, 11p

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Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis.

• Authors : Scarneo, Scott; Hughes, Philip; Freeze, Robert

• Source: ACS Chemical Biology; 3/18/2022, Vol. 17 Issue 3, p536-544, 9p

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Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice.

• Authors : Scarneo, Scott A.; Eibschutz, Liesl S.; Bendele, Phillip J.

• Source: Arthritis Research & Therapy; 12/17/2019, Vol. 21 Issue 1, p1-10, 10p

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Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion.

• Authors : Scarneo, Scott A.; Mansourati, Antoine; Eibschutz, Liesl S.

• Source: Scientific Reports; 11/19/2018, Vol. 8 Issue 1, p1-1, 1p

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A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase.

• Authors : Scarneo, Scott A.¹; Hughes, Philip F.¹; Yang, Kelly W.¹

Subjects: *PROTEIN kinases; *INTERLEUKIN-1; *INTERLEUKIN receptorsIRAQ

• Source: Journal of Biological Chemistry. 2/7/2020, Vol. 295 Issue 6, p1565-1574. 10p.

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TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases.

• Authors : Totzke J; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.; Scarneo SA

Subjects: Inflammation/Inflammation/Inflammation/*metabolism ; MAP Kinase Kinase Kinases/MAP Kinase Kinase Kinases/MAP Kinase Kinase Kinases/*metabolism ; Tumor Necrosis Factor-alpha/Tumor Necrosis Factor-alpha/Tumor Necrosis Factor-alpha/*metabolism

• Source: Open biology [Open Biol] 2020 Sep; Vol. 10 (9), pp. 200099. Date of Electronic Publication: 2020 Sep 02.Publisher: Royal Society Pub Country of Publication: England NLM ID: 101580419 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades.

• Authors : Scarneo SA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.; Yang KW

• Source: Oncotarget [Oncotarget] 2020 May 26; Vol. 11 (21), pp. 1961-1970. Date of Electronic Publication: 2020 May 26 (Print Publication: 2020).Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: eCollection Cited Medium: Internet ISSN:

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