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Structure-based optimization of MurF inhibitors.

• Authors : Stamper GF; Global Pharmaceutical Research & Development, Department of Structural Biology, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. ; Longenecker KL

Subjects: Structure-Activity Relationship*; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry ; Peptide Synthases/Peptide Synthases/Peptide Synthases/*antagonists & inhibitors

• Source: Chemical biology & drug design [Chem Biol Drug Des] 2006 Jan; Vol. 67 (1), pp. 58-65.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Print ISSN: 1747-0277 (Print)

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Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.

• Authors : Longenecker KL; Department of Structural Biology, R46Y, Building AP10, 100 Abbott Park Road, Abbott Park, IL 60064, USA. ; Stamper GF

Subjects: Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry ; Peptide Synthases/Peptide Synthases/Peptide Synthases/*antagonists & inhibitors ; Peptide Synthases/Peptide Synthases/Peptide Synthases/*chemistry

• Source: Protein science : a publication of the Protein Society [Protein Sci] 2005 Dec; Vol. 14 (12), pp. 3039-47.Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Print

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Effect of a Y265F mutant on the transamination-based cycloserine inactivation of alanine racemase.

• Authors : Fenn TD; Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA.; Holyoak T

Subjects: Mutation*; Alanine Racemase/Alanine Racemase/Alanine Racemase/*chemistry ; Cycloserine/Cycloserine/Cycloserine/*pharmacology

• Source: Biochemistry [Biochemistry] 2005 Apr 12; Vol. 44 (14), pp. 5317-27.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Print ISSN:

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Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.

• Authors : Sanders WJ; Infectious Disease Research, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, Illinois 60064-6217, USA. ; Nienaber VL

Subjects: Aldehyde-Lyases/Aldehyde-Lyases/Aldehyde-Lyases/*antagonists & inhibitors ; Aldehyde-Lyases/Aldehyde-Lyases/Aldehyde-Lyases/*chemistry ; Benzoates/Benzoates/Benzoates/*chemistry

• Source: Journal of medicinal chemistry [J Med Chem] 2004 Mar 25; Vol. 47 (7), pp. 1709-18.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN:

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Structure-activity relationships of novel potent MurF inhibitors.

• Authors : Gu YG; Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, IL 60064, USA. ; Florjancic AS

Subjects: Bacterial Proteins/Bacterial Proteins/Bacterial Proteins/*antagonists & inhibitors ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

• Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Jan 05; Vol. 14 (1), pp. 267-70.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X

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A side reaction of alanine racemase: transamination of cycloserine.

• Authors : Fenn TD; Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA.; Stamper GF

Subjects: Alanine Racemase/Alanine Racemase/Alanine Racemase/*chemistry ; Alanine Racemase/Alanine Racemase/Alanine Racemase/*metabolism ; Cycloserine/Cycloserine/Cycloserine/*chemistry

• Source: Biochemistry [Biochemistry] 2003 May 20; Vol. 42 (19), pp. 5775-83.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Print ISSN:

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Reaction of alanine racemase with 1-aminoethylphosphonic acid forms a stable external aldimine

• Authors : Stamper GF; Morollo AA; Ringe D

• Source: Biochemistry [Biochemistry] 1999 May 18; Vol. 38 (20), pp. 6714.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Internet ISSN:

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Reaction of alanine racemase with 1-aminoethylphosphonic acid forms a stable external aldimine.

• Authors : Stamper GF; Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02254, USA.; Morollo AA

Subjects: Alanine Racemase/Alanine Racemase/Alanine Racemase/*chemistry ; Aminoethylphosphonic Acid/Aminoethylphosphonic Acid/Aminoethylphosphonic Acid/*chemistry ; Imines/Imines/Imines/*chemistry

• Source: Biochemistry [Biochemistry] 1998 Jul 21; Vol. 37 (29), pp. 10438-45.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Print ISSN:

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