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Promising use of metformin in treating neurological disorders: biomarker-guided therapies.

• Authors : Loan, Allison; Syal, Charvi; Lui, Margarita

• Source: Neural Regeneration Research; May2024, Vol. 19 Issue 5, p1045-1055, 11p

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Metformin Preconditioning of Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells Promotes Their Engraftment and Improves Post-Stroke Regeneration and Recovery.

• Authors : Ould-Brahim, Fares; Sarma, Sailendra Nath; Syal, Charvi

• Source: Stem Cells & Development; Aug2018, Vol. 27 Issue 16, p1085-1096, 12p

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Ectopic expression of aPKC-mediated phosphorylation in p300 modulates hippocampal neurogenesis, CREB binding and fear memory differently with age.

• Authors : Syal, Charvi; Seegobin, Matthew; Sarma, Sailendra Nath

• Source: Scientific Reports; 9/10/2018, Vol. 8 Issue 1, p1-1, 1p

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Metformin promotes CNS remyelination and improves social interaction following focal demyelination through CBP Ser436 phosphorylation.

• Authors : Kosaraju, Jayasankar¹ (AUTHOR); Seegobin, Matthew¹ (AUTHOR); Gouveia, Ayden¹ (AUTHOR)

Subjects: *SOCIAL interaction; *METFORMIN; *WHITE matter (Nerve tissue)UNITED States. Food & Drug Administration

• Source: Experimental Neurology. Dec2020, Vol. 334, pN.PAG-N.PAG. 1p.

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Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain.

• Authors : Voronova, Anastassia¹; Yuzwa, Scott A.¹; Wang, Beatrix S.¹

Subjects: *FRACTALKINE; *OLIGODENDROGLIA; *INTERNEURONS

• Source: Neuron. May2017, Vol. 94 Issue 3, p500-516.e9. 1p.

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Biomarker-guided drug therapy: personalized medicine for treating Alzheimer's disease.

• Authors : Syal C; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Wang J

• Source: Neural regeneration research [Neural Regen Res] 2021 Oct; Vol. 16 (10), pp. 2010-2011.Publisher: Wolters Kluwer Health, Medknow Country of Publication: India NLM ID: 101316351 Publication Model: Print Cited Medium: Print ISSN:

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Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease.

• Authors : Syal C; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*drug therapy ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*enzymology ; Metformin/Metformin/Metformin/*pharmacology

• Source: Theranostics [Theranostics] 2020 May 15; Vol. 10 (14), pp. 6337-6360. Date of Electronic Publication: 2020 May 15 (Print Publication: 2020).Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet

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