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Coaggregation of polyglutamine (polyQ) proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis.

• Authors : Hong JY; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Beijing 100049, China.

Subjects: Proteostasis* ; Neurodegenerative Diseases*; Humans

• Source: Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2023 May 11; Vol. 55 (5), pp. 736-748.Publisher: China Science Publishing & Media Ltd Country of Publication: China NLM ID: 101206716 Publication Model: Print Cited Medium: Internet ISSN:

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PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates.

• Authors : Yue HW; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, People's Republic of China.; University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.

Subjects: Ataxin-3/Ataxin-3/Ataxin-3/*metabolism ; HSP40 Heat-Shock Proteins/HSP40 Heat-Shock Proteins/HSP40 Heat-Shock Proteins/*metabolism ; Molecular Chaperones/Molecular Chaperones/Molecular Chaperones/*metabolism

• Source: Scientific reports [Sci Rep] 2021 Apr 09; Vol. 11 (1), pp. 7815. Date of Electronic Publication: 2021 Apr 09.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Author Correction: Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation.

• Authors : Hong JY; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, P.R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P.R. China.

• Source: Scientific reports [Sci Rep] 2020 Jun 09; Vol. 10 (1), pp. 9519. Date of Electronic Publication: 2020 Jun 09.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation.

• Authors : Hong JY; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, P.R. China.; University of Chinese Academy of Sciences, Beijing, 100049, P.R. China.

Subjects: Molecular Dynamics Simulation* ; Protein Multimerization*; Amyloid/Amyloid/Amyloid/*chemistry

• Source: Scientific reports [Sci Rep] 2019 May 16; Vol. 9 (1), pp. 7481. Date of Electronic Publication: 2019 May 16.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases.

• Authors : Ge D; School of Biological Science and Technology, University of Jinan, Jinan, 250022, China. .; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan, 250022, China. .

Subjects: Cardiovascular Physiological Phenomena*; Cardiovascular Diseases/Cardiovascular Diseases/Cardiovascular Diseases/*physiopathology ; Phosphorylcholine/Phosphorylcholine/Phosphorylcholine/*analogs & derivatives

• Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2018 Dec; Vol. 39 (12), pp. 1830-1836. Date of Electronic Publication: 2018 Jul 26.Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet

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PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin.

• Authors : Yang H; State Key Laboratory of Molecular Biology, Chinese Academy of Sciences (CAS) Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology (SIBCB), University of CAS, Shanghai, China.; State Key Laboratory of Genetic Engineering, School of Life Sciences, Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai, China.

Subjects: Ataxin-3/Ataxin-3/Ataxin-3/*metabolism ; Cell Cycle Proteins/Cell Cycle Proteins/Cell Cycle Proteins/*metabolism ; DNA Repair Enzymes/DNA Repair Enzymes/DNA Repair Enzymes/*metabolism

• Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2018 Jun; Vol. 32 (6), pp. 2923-2933. Date of Electronic Publication: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic

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HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19.

• Authors : He WT; State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, P. R. China.; Xue W

Subjects: Endopeptidases*/Endopeptidases*/Endopeptidases*/chemistry ; Endopeptidases*/Endopeptidases*/Endopeptidases*/genetics ; Endopeptidases*/Endopeptidases*/Endopeptidases*/metabolism

• Source: Scientific reports [Sci Rep] 2017 Nov 01; Vol. 7 (1), pp. 14797. Date of Electronic Publication: 2017 Nov 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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Construction of a linker library with widely controllable flexibility for fusion protein design.

• Authors : Li G; Department of Chemical Engineering, Tsinghua University, Beijing, 10084, China.; Key Laboratory of Industrial Biocatalysis, Ministry of Education, Beijing, China.

Subjects: Artificial Gene Fusion*; Protein Engineering/Protein Engineering/Protein Engineering/*methods ; Recombinant Fusion Proteins/Recombinant Fusion Proteins/Recombinant Fusion Proteins/*genetics

• Source: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2016 Jan; Vol. 100 (1), pp. 215-25. Date of Electronic Publication: 2015 Sep 22.Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy.

• Authors : Yue HW; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China.; Liu J

Subjects: Membrane Microdomains/Membrane Microdomains/Membrane Microdomains/*drug effects ; Myocytes, Cardiac/Myocytes, Cardiac/Myocytes, Cardiac/*drug effects ; PTEN Phosphohydrolase/PTEN Phosphohydrolase/PTEN Phosphohydrolase/*metabolism

• Source: Biochimica et biophysica acta [Biochim Biophys Acta] 2015 Sep; Vol. 1851 (9), pp. 1186-93. Date of Electronic Publication: 2015 Apr 12.Publisher: Elsevier Pub. Co Country of Publication: Netherlands NLM ID: 0217513 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Sphingosylphosphorylcholine in cancer progress.

• Authors : Yue HW; Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University Jinan 250100, China.; Jing QC

• Source: International journal of clinical and experimental medicine [Int J Clin Exp Med] 2015 Aug 15; Vol. 8 (8), pp. 11913-21. Date of Electronic Publication: 2015 Aug 15 (Print Publisher: e-Century Pub. Corp Country of Publication: United States NLM ID: 101471010 Publication Model: eCollection Cited Medium: Print ISSN:

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