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Impact of sulfation pattern on the conformation and dynamics of sulfated fucan oligosaccharides as revealed by NMR and MD.
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- Author(s): Queiroz, Ismael N. L.; Xiaocong Wang; Glushka, John N.; Santos, Gustavo R. C.; Valente, Ana P.; Prestegard, James H.; Woods, Robert J.; Mourão, Paulo A. S.; Pomin, Vitor H.
- Source:
Glycobiology; May2015, Vol. 25 Issue 5, p535-547, 13p- Subject Terms:
- Source:
- Additional Information
- Abstract: Sulfated fucans fromsea urchin egg jelly expresswell-defined chemical structures that vary with species. This species specificity regulates the sperm acrosome reaction, a critical step to assure intraspecific fertilization. In addition, these polysaccharides are involved in other biological activities such as anticoagulation. Although sulfation patterns are relevant to the levels of response in both activities, conformation and dynamics of these glycans are also contributing factors. However, data about these features of sulfated fucans are very rare. To address this, we have employed nuclear magnetic resonance experiments combined with molecular dynamics on structurally defined oligosaccharides derived from two sulfated fucans. The results have indicated that the oligosaccharides are flexible in solution. Ring conformation of their composing units displays just the ¹C
4 chair configuration. In a particular octasaccharide, composed of two tetrasaccharide sequences, inter-residual hydrogen bonds play a role to decrease dynamics in these repeating units. Conversely, the linking disaccharide [-3)-α-L-Fucp-2(OSO3 -)-(1-3)-α-L-Fucp-4(OSO3 -)-(1-] located right between the two tetrasaccharide units has amplified motions suggested to be promoted by electrostatic repulsion of sulfates on opposite sides of the central glycosidic bond. This conjunction of information about conformation and dynamics of sulfated fucan oligosaccharides provides new insights to explain how these glycans behave free in solution and influenced by sulfation patterns. It may also serve for future studies concerning structure-function relationship of sulfated fucans, especially those involving sea urchin fertilization and anticoagulation [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Glycobiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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