[Clinical study on treatment of nasopharyngeal carcinoma by radio- and chemotherapy with supplementary moxibustion on Shenque point].

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  • Author(s): Chen K;Chen K; Jiang Y; Wen H
  • Source:
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine [Zhongguo Zhong Xi Yi Jie He Za Zhi] 2000 Oct; Vol. 20 (10), pp. 733-5.
  • Publication Type:
    Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • Language:
    Chinese
  • Additional Information
    • Source:
      Publisher: Gai yan jiu yuan Country of Publication: China NLM ID: 9211576 Publication Model: Print Cited Medium: Print ISSN: 1003-5370 (Print) Linking ISSN: 10035370 NLM ISO Abbreviation: Zhongguo Zhong Xi Yi Jie He Za Zhi Subsets: MEDLINE
    • Publication Information:
      Publication: Beijing : Gai yan jiu yuan
      Original Publication: Beijing : Gai yan jiu yuan, 1992-
    • Subject Terms:
      Moxibustion*; Antineoplastic Combined Chemotherapy Protocols/*therapeutic use ; Carcinoma, Squamous Cell/*therapy ; Nasopharyngeal Neoplasms/*therapy; Acupuncture Points ; Adult ; Aged ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/radiotherapy ; Cisplatin ; Combined Modality Therapy ; Doxorubicin ; Female ; Humans ; Male ; Middle Aged ; Nasopharyngeal Neoplasms/mortality ; Nasopharyngeal Neoplasms/radiotherapy ; Radiotherapy, High-Energy ; Survival Rate
    • Abstract:
      Objective: To evaluate the effect of supplementary moxibustion in treating III, IV a stage nasopharyngeal carcinoma (NPC) with radio- and chemotherapy.
      Methods: Fifty-six cases of NPC were randomly divided into two groups, 28 in each group. They were treated with radiotherapy in routine or chemotherapy adopting AD protocol. Salt-separated moxibustion on Shenque (Ren 8) point was given to the treated group from beginning of radio- and chemotherapy for 30 times as one therapeutic course.
      Results: The remission rate in the two groups after radio- and chemotherapy was not different significantly. The toxic and side-effect occurrence was less in the treated group than that in the control group (P < 0.05). The 5-year local control rates of NPC and cervical lymphnode were 85.7% and 85.0% in the treated group, which were higher than those in the control group (78.6% and 78.9%). The 5-year survival rate in the two groups were 50.0% and 35.7% respectively. After radio- and chemotherapy, the blood content of malonyldialdehyde (MDA), middle molecular substance and sulfhydryl reduced the SOD activity ascended in the treated group, the difference was significant as compared with those in the control group (P < 0.05, P < 0.01).
      Conclusion: The supplementary moxibustion on Shenque point could obviously reduce the toxic side-effect of advanced NPC patients treated with radio- and chemotherapy.
    • Accession Number:
      80168379AG (Doxorubicin)
      Q20Q21Q62J (Cisplatin)
    • Subject Terms:
      AP protocol 1
    • Publication Date:
      Date Created: 20020410 Date Completed: 20030627 Latest Revision: 20161018
    • Publication Date:
      20231215
    • Accession Number:
      11938806