[The prognostic assessment of patient survival in chronic myeloleukemia].

Prognosticheskaia otsenka vyzhivaemosti bol'nykh khronicheskim mieloleĭkozom.

Publisher: ZAO 'Konsilium Medikum Country of Publication: Russia (Federation) NLM ID: 2984818R Publication Model: Print Cited Medium: Print ISSN: 0040-3660 (Print) Linking ISSN: 00403660 NLM ISO Abbreviation: Ter Arkh Subsets: MEDLINE

Publication: <2018- > : Moskva : ZAO 'Konsilium Medikum'
Original Publication: Moskva : Izdatelʹstvo Medit︠s︡ina

Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*mortality; Age Factors ; Chi-Square Distribution ; Humans ; Latvia/epidemiology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/blood ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/epidemiology ; Prognosis ; Regression Analysis ; Retrospective Studies ; Sex Factors ; Survival Analysis

The prognostic significance of the clinicohematological and kinetic characteristics was analyzed in patients suffering from chronic myeloleukemia with the aid of computerized methods of linear and nonlinear regression (Cox's model). New predictors not previously used in patients with chronic myeloleukemia are offered: the ratio of variation of the integral optic density of mature neutrophil nuclei stained with methylene blue and the general marker index (GMI) of circulating granulocytes with 3H-thymidine in vitro. The relationship between the GMI and the survival when estimated according to chi 2 in Cox's model surpassed 3-11-fold that for the clinicohematological characteristics. A regression equation was derived, allowing the probable patient's survival (in months) to be predicted.

Date Created: 19910101 Date Completed: 19920430 Latest Revision: 20071115

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