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Characterization of invasive Group B Streptococcus isolates from Western Australian infants, 2004-2020.
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- Author(s): Hilpipre G;Hilpipre G;Hilpipre G; Furfaro LL; Furfaro LL; Porter M; Porter M; Blyth CC; Blyth CC; Blyth CC; Blyth CC; Blyth CC; Yeoh DK; Yeoh DK; Yeoh DK; Yeoh DK
- Source:
Journal of medical microbiology [J Med Microbiol] 2024 Apr; Vol. 73 (4).- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Microbiology Society Country of Publication: England NLM ID: 0224131 Publication Model: Print Cited Medium: Internet ISSN: 1473-5644 (Electronic) Linking ISSN: 00222615 NLM ISO Abbreviation: J Med Microbiol Subsets: MEDLINE
- Publication Information: Publication: 2015- : London : Microbiology Society
Original Publication: 1968-1995: Edinburgh, Livingstone. - Subject Terms: Streptococcal Infections*/drug therapy ; Vaccines*/therapeutic use; Infant ; Humans ; Streptococcus agalactiae ; Western Australia/epidemiology ; Australia/epidemiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Penicillins ; Serogroup ; Microbial Sensitivity Tests ; Drug Resistance, Bacterial
- Abstract: Background. Invasive Group B Streptococcus (GBS; Streptococcus agalactiae ) remains a leading cause of infant morbidity and mortality. Intrapartum antibiotic prophylaxis (IAP) has been implemented in many countries with a reduction in early-onset disease, but an effective vaccine may further reduce the disease burden. Candidate vaccines targeting capsular polysaccharides and surface proteins are now in clinical trials. Methods. Using whole-genome sequencing and phenotypic antimicrobial susceptibility testing, we characterized sterile-site GBS isolates recovered from Western Australian infants between 2004 and 2020. Characteristics were compared between three time periods: 2004-2008, 2009-2015 and 2016-2020. Results. A total of 135 isolates were identified. The proportion of serotype III (22.7 % in Period 1 to 47.9 % in Period 3, P =0.04) and clonal complex 17 (13.6-39.6 %, P =0.01) isolates increased over time. Overall coverage of vaccines currently being trialled was >95 %. No isolates were penicillin resistant (MIC>0.25 mg l -1 ), but 21.5 % of isolates had reduced penicillin susceptibility (MIC>0.12 mg l -1 ) and penicillin MIC increased significantly over time ( P =0.04). Clindamycin resistance increased over time to 45.8 % in the latest period. Conclusions. Based on comprehensive characterization of invasive infant GBS in Western Australia, we found that coverage for leading capsular polysaccharide and surface protein vaccine candidates was high. The demonstrated changes in serotype and molecular type highlight the need for ongoing surveillance, particularly with regard to future GBS vaccination programmes. The reduced susceptibility to IAP agents over time should inform changes to antibiotic guidelines.
- Contributed Indexing: Keywords: GBS; Group B Streptococcus; capsular serotypes; infant; multi-locus sequence types; resistance; surface proteins; vaccine
- Accession Number: 0 (Anti-Bacterial Agents)
0 (Penicillins)
0 (Vaccines) - Publication Date: Date Created: 20240403 Date Completed: 20240404 Latest Revision: 20240404
- Publication Date: 20240404
- Accession Number: 10.1099/jmm.0.001822
- Accession Number: 38567639
- Source:
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