Ovarian transplantation between monozygotic twins discordant for premature ovarian failure.

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  • Additional Information
    • Source:
      Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: Boston, Massachusetts Medical Society.
    • Subject Terms:
      Pregnancy*; Diseases in Twins/*surgery ; Infertility, Female/*surgery ; Ovary/*transplantation ; Primary Ovarian Insufficiency/*surgery; Adult ; Female ; Humans ; Infant, Newborn ; Infertility, Female/etiology ; Ovary/abnormalities ; Ovary/cytology ; Primary Ovarian Insufficiency/complications ; Twins, Monozygotic
    • Abstract:
      Monozygotic 24-year-old twins presented with discordant ovarian function. One had had premature ovarian failure at the age of 14 years, whereas her sister had normal ovaries and three naturally conceived children. After unsuccessful egg-donation therapy, the sterile twin received a transplant of ovarian cortical tissue from her sister by means of a minilaparotomy. Within three months after transplantation, the recipient's cycles resumed and serum gonadotropin levels fell to the normal range. During the second cycle, she conceived, and her pregnancy progressed uneventfully. At 38 weeks' gestation, she delivered a healthy-appearing female infant.
      (Copyright 2005 Massachusetts Medical Society.)
    • Publication Date:
      Date Created: 20050609 Date Completed: 20050712 Latest Revision: 20101118
    • Publication Date:
      20231215
    • Accession Number:
      10.1056/NEJMoa043157
    • Accession Number:
      15941849