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Altered regional brain activity moderating the relationship between childhood trauma and depression severity.
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- Author(s): Luo Z;Luo Z;Luo Z;Luo Z;Luo Z; Li W; Li W; Li W; Li W; Li W; Zhang F; Zhang F; Zhang F; Zhang F; Zhang F; Hu Z; Hu Z; Hu Z; Hu Z; You Z; You Z; You Z; You Z; You Z; Wang C; Wang C; Wang C; Wang C; Lan X; Lan X; Lan X; Lan X; Mai S; Mai S; Mai S; Mai S; Chen X; Chen X; Chen X; Chen X; Zeng Y; Zeng Y; Zeng Y; Zeng Y; Chen Y; Chen Y; Chen Y; Chen Y; Liang Y; Liang Y; Liang Y; Liang Y; Chen Y; Chen Y; Chen Y; Chen Y; Zhou Y; Zhou Y; Zhou Y; Zhou Y; Ning Y; Ning Y; Ning Y; Ning Y; Ning Y
- Source:
Journal of affective disorders [J Affect Disord] 2024 Apr 15; Vol. 351, pp. 211-219. Date of Electronic Publication: 2024 Jan 18.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
- Publication Information: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
- Subject Terms:
- Abstract: Objective: Childhood trauma (CT) is a major environmental risk factor for an adverse course and treatment outcome of major depressive disorder (MDD). Evidence suggests that an altered regional brain activity may play a crucial role in the relationship between CT and MDD. This study aimed to clarify the relationship between CT, regional brain activity, and depression severity.
Methods: In this study, 96 patients with MDD and 82 healthy controls (HCs) participated. Regional brain activity was measured using the fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). These measures were compared between the MDD and HC groups, and the values of different brain regions were extracted as moderators.
Results: Increased fALFF and ReHo values were observed in the left middle temporal gyrus in the MDD group compared with the HC group (p < 0.001). Furthermore, the fALFF and ReHo values moderated the positive correlation between the Childhood Trauma Questionnaire (CTQ) score, 17-item Hamilton Depression Rating Scale (HAMD-17) total score, and retardation factor score in the MDD group (all, p < 0.05). Finally, as the fALFF and ReHo values increased, the positive correlations between CTQ, HAMD-17 total, and retardation dimension scores became stronger.
Conclusion: Our study highlighted the crucial role of altered brain function in connecting childhood maltreatment with depressive symptoms. Our findings indicate that an altered regional brain activity could explain the potential neurobiological mechanisms of MDD symptoms, offering the opportunity to function as a powerful diagnostic biomarker.
Competing Interests: Declaration of competing interest The authors declare no potential or actual conflicts of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.) - Contributed Indexing: Keywords: Childhood trauma; Major depressive disorder; Moderation; ReHo; Retardation; fALFF
- Subject Terms: Childhood Trauma Questionnaire
- Publication Date: Date Created: 20240120 Date Completed: 20240228 Latest Revision: 20240228
- Publication Date: 20240228
- Accession Number: 10.1016/j.jad.2024.01.162
- Accession Number: 38244793
- Source:
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