Retrospective study of serial polysomnograms of bronchopulmonary dysplasia patients with oxygen dependence.

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  • Additional Information
    • Source:
      Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8510590 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0496 (Electronic) Linking ISSN: 10990496 NLM ISO Abbreviation: Pediatr Pulmonol Subsets: MEDLINE
    • Publication Information:
      Publication: <2005-> : Hoboken, NJ : Wiley-Liss
      Original Publication: [Philadelphia, PA] : W.B. Saunders, [c1985-
    • Subject Terms:
      Polysomnography* ; Oxygen Inhalation Therapy*/methods ; Bronchopulmonary Dysplasia*/therapy ; Bronchopulmonary Dysplasia*/physiopathology; Humans ; Retrospective Studies ; Male ; Female ; Infant, Newborn ; Oxygen ; Gestational Age ; Infant ; Infant, Premature ; Oxygen Saturation
    • Abstract:
      Introduction: This retrospective study describes characteristics of serial polysomnograms (PSGs) of BPD patients on home oxygen therapy and describes PSG parameters associated with discontinuation of supplemental oxygen.
      Methods: A single-center study was performed at Children's Hospital Los Angeles, where serial PSGs for 44 patients with BPD infants discharged on home oxygen therapy were extracted for maximum of five PSGs or until oxygen discontinuation. Clinical and polysomnography data was collected. Characteristics of PSG1 were compared amongst the patients who were weaned from oxygen after PSG2 and PSG3.
      Results: Of 44 patients, 68.2% of patients were males with median birth gestational age of 26 weeks (IQR: 24.6-28.1), median birthweight of 777.5 g (IQR: 632.5-1054 g) and 77.3% of the cohort had severe BPD. A total of 138 PSGs were studied between all 44 patients serially. When comparing PSG1 and PSG2 parameters, statistically significant improvement was noted in multiple parameters. Median baseline SpO 2 , peak RR, and average PETCO 2 were found to be potential predictors of prolonged oxygen use. Gestational age and birth weight were not associated with prolonged oxygen use after PSG3. The median age of oxygen discontinuation was calculated to be about 2 years of age.
      Conclusions: The severity of hypoxia and tachypnea on initial infant PSG are associated with prolonged oxygen therapy past 2 years of age. Growth and development of lungs with maturation of control of breathing help improve these parameters over time regardless of BPD severity. The study may inform discussions between providers and parents for patients discharged home on oxygen therapy.
      (© 2024 Wiley Periodicals LLC.)
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    • Grant Information:
      UL1TR001855 National Center for Advancing Translational Science; UL1TR000130 National Center for Advancing Translational Science
    • Contributed Indexing:
      Keywords: bronchopulmonary dysplasia; home oxygen therapy; infant sleep study; polysomnography; prematurity
    • Accession Number:
      S88TT14065 (Oxygen)
    • Publication Date:
      Date Created: 20240227 Date Completed: 20240429 Latest Revision: 20240429
    • Publication Date:
      20240501
    • Accession Number:
      10.1002/ppul.26930
    • Accession Number:
      38411384