Self-Reported Cancer-Related Cognitive Impairment in Patients With Breast Cancer Is Associated With Potassium Channel Gene Polymorphisms.

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  • Additional Information
    • Source:
      Publisher: Oncology Nursing Society Country of Publication: United States NLM ID: 7809033 Publication Model: Print Cited Medium: Internet ISSN: 1538-0688 (Electronic) Linking ISSN: 0190535X NLM ISO Abbreviation: Oncol Nurs Forum Subsets: MEDLINE
    • Publication Information:
      Publication: Pittsburgh, PA : Oncology Nursing Society
      Original Publication: New York, Oncology Nursing Society.
    • Subject Terms:
      Breast Neoplasms*/genetics ; Breast Neoplasms*/complications ; Breast Neoplasms*/psychology ; Cognitive Dysfunction*/etiology ; Cognitive Dysfunction*/genetics ; Polymorphism, Single Nucleotide* ; Self Report*; Humans ; Female ; Middle Aged ; Aged ; Adult ; Potassium Channels/genetics ; Aged, 80 and over
    • Abstract:
      Objectives: To evaluate for associations of polymorphisms for potassium channel genes in patients with breast cancer who were classified as having high or low-moderate levels of cancer-related cognitive impairment (CRCI).
      Sample & Setting: 397 women who were scheduled to undergo surgery for breast cancer on one breast were recruited from breast care centers located in a comprehensive cancer center, two public hospitals, and four community practices.
      Methods & Variables: CRCI was assessed using the Attentional Function Index prior to and for six months after surgery. The attentional function classes were identified using growth mixture modeling.
      Results: Differences between patients in the high versus low-moderate attentional function classes were evaluated. Six single nucleotide polymorphisms for potassium channel genes were associated with low-moderate class membership.
      Implications for Nursing: The results contribute to knowledge of the mechanisms for CRCI. These findings may lead to the identification of high-risk patients and the development of novel therapeutics.
    • Contributed Indexing:
      Keywords: attentional function; breast cancer; cancer-related cognitive impairment
    • Accession Number:
      0 (Potassium Channels)
    • Publication Date:
      Date Created: 20240426 Date Completed: 20240426 Latest Revision: 20240430
    • Publication Date:
      20240430
    • Accession Number:
      10.1188/24.ONF.263-274
    • Accession Number:
      38668911