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Academic Journal

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.

Authors : Balıkçı, Esra; Marques, Anne-Sophie M. C.; Bauer, Ludwig G.

Source: Journal of Medicinal Chemistry; 5/9/2024, Vol. 67 Issue 9, p7245-7259, 15p

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Academic Journal

A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target.

Authors : Kennedy, Cassandra R.; Goya Grocin, Andrea; Kovačič, Tristan

Source: ACS Chemical Biology; 6/18/2021, Vol. 16 Issue 6, p982-990, 9p

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Academic Journal

Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs.

Authors : Ward JA; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, U.K.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.

Subjects: Azepines/Azepines/Azepines/*pharmacology ; Benzylidene Compounds/Benzylidene Compounds/Benzylidene Compounds/*pharmacology ; Deubiquitinating Enzymes/Deubiquitinating Enzymes/Deubiquitinating Enzymes/*antagonists & inhibitors

Source: Journal of medicinal chemistry [J Med Chem] 2020 Apr 09; Vol. 63 (7), pp. 3756-3762. Date of Electronic Publication: 2020 Mar 19.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic

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Report

Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.

Authors : Ward JA; Department of Chemistry, Imperial College London , London, SW7 2AZ, United Kingdom.; McLellan L

Subjects: Molecular Probes/Molecular Probes/Molecular Probes/*chemistry ; Neoplasms/Neoplasms/Neoplasms/*enzymology ; Proteomics/Proteomics/Proteomics/*methods

Source: ACS chemical biology [ACS Chem Biol] 2016 Dec 16; Vol. 11 (12), pp. 3268-3272. Date of Electronic Publication: 2016 Oct 31.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic

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