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Subject : cytochrome p-450 enzyme system Filter by : Author

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Academic Journal

Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450.

Authors : Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA. ; Liu L

Subjects: Models, Biological*; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*metabolism ; Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/*methods

Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2011 Mar; Vol. 39 (3), pp. 373-82. Date of Electronic Publication: 2010 Dec 08.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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Academic Journal

Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.

Authors : Kikuchi R; Non Clinical Safety, Department of Drug Metabolism and Pharmacokinetics, Viral Disease Biology, and Molecular Medicine Laboratories (P.O.), Roche Palo Alto, Palo Alto, California, USA.; McCown M

Subjects: Carrier Proteins/Carrier Proteins/Carrier Proteins/*biosynthesis ; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*biosynthesis ; Hepatitis C/Hepatitis C/Hepatitis C/*metabolism

Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2010 Nov; Vol. 38 (11), pp. 1954-61. Date of Electronic Publication: 2010 Aug 06.Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model:

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