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Wando Mount Pleasant Library
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Village Library
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Mt. Pleasant Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Early clinical response to tofacitinib treatment as a predictor of subsequent efficacy: Results from two phase 3 studies of patients with moderate-to-severe plaque psoriasis.
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- Author(s): Tan, Huaming; Valdez, Hernan; Griffiths, Chris E.M.; Mrowietz, Ulrich; Tallman, Anna; Wolk, Robert; Gordon, Kenneth
- Source:
Journal of Dermatological Treatment; Feb2017, Vol. 28 Issue 1, p3-7, 5p- Subject Terms:
- Source:
- Additional Information
- Abstract: Background:The ability to predict response to psoriasis treatments has important implications. Tofacitinib is an oral JAK inhibitor being investigated for psoriasis. Objective:The objective of this study is to identify and validate the clinical predictors of responses in psoriasis patients treated with tofacitinib. Methods:Selected baseline characteristics or early improvement in Psoriasis Area and Severity Index (PASI) in the phase 3 tofacitinib study OPT 1 (NCT01276639) were evaluated as predictors for a clinical response (75% improvement in PASI [PASI75]) at week 16. Predictive ability was assessed by the area-under-the-receiver operating characteristic curve (AUC-ROC). The predictive ability of the identified variables was validated with study OPT 2 (NCT01309737). Results:PASI improvement at weeks 8 and 12 demonstrated good discriminatory abilities to predict PASI75 response at week 16 (AUC-ROC ≥86% and 94%, respectively) in OPT 1. Validation with PASI50 response at week 8 in OPT 2 to predict PASI75 response at week 16 showed that the sensitivity, specificity, PPV, and NPV were 88%, 69%, 80%, and 81%, respectively, in tofacitinib-treated subjects. Conclusion:Achieving a PASI50 response after 8 weeks of treatment with tofacitinib in psoriasis patients appears to be a reliable predictor of achieving a PASI75 response at week 16.Trial registration:clinicaltrials.gov: NCT01276639 and NCT01309737 [ABSTRACT FROM PUBLISHER]
- Abstract: Copyright of Journal of Dermatological Treatment is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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