Hemoglobin concentration in pregnancy and perinatal mortality: a London-based cohort study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Little MP;Little MP; Brocard P; Elliott P; Steer PJ
  • Source:
    American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2005 Jul; Vol. 193 (1), pp. 220-6.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0370476 Publication Model: Print Cited Medium: Print ISSN: 0002-9378 (Print) Linking ISSN: 00029378 NLM ISO Abbreviation: Am J Obstet Gynecol Subsets: MEDLINE
    • Publication Information:
      Publication: <2005->: New York : Elsevier
      Original Publication: St. Louis.
    • Subject Terms:
      Infant Mortality*; Hemoglobins/*metabolism ; Pregnancy/*blood; Birth Weight ; Cohort Studies ; Databases, Factual ; Female ; Humans ; Incidence ; Infant, Newborn ; Infant, Premature ; Logistic Models ; London/epidemiology ; Osmolar Concentration ; Pregnancy Outcome/epidemiology ; Prospective Studies
    • Abstract:
      Objective: Failure of fetal growth during pregnancy, and preterm birth, are the major causes of stillbirth and early neonatal death. The objective of the study was to determine the association between maternal hemoglobin concentration during pregnancy and perinatal mortality.
      Study Design: The design was prospective, using data on 222,614 first singleton pregnancies in the St Mary's Maternity Information System database in the Northwest Thames region of London.
      Results: The association of perinatal mortality with maternal hemoglobin at first antenatal check was not statistically significant (P>.10), but a statistically significant (P<.001) U-shaped pattern was found with lowest recorded maternal hemoglobin concentration. Both early neonatal mortality and stillbirth rates were statistically significantly (P<.005) associated with lowest maternal hemoglobin concentration. The relationship of lowest hemoglobin with early neonatal mortality was largely mediated by the effect of preterm birth, and that between lowest hemoglobin and stillbirth by fetal growth restriction. The lowest perinatal mortality was associated with a lowest recorded maternal hemoglobin concentration of between 9-11 g/dL.
      Conclusion: There is an optimal range of lowest hemoglobin concentration in pregnancy, and on either side of this perinatal mortality is increased. The effect of lowest hemoglobin is largely mediated through associations with preterm birth and fetal growth restriction.
    • Comments:
      Comment in: Am J Obstet Gynecol. 2006 Nov;195(5):1499-500; author reply 1500. (PMID: 16626614)
      Comment in: Am J Obstet Gynecol. 2006 Jul;195(1):336-7; author reply 337. (PMID: 16813770)
    • Accession Number:
      0 (Hemoglobins)
    • Publication Date:
      Date Created: 20050716 Date Completed: 20050811 Latest Revision: 20220410
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.ajog.2004.11.053
    • Accession Number:
      16021083