Occupational extremely low-frequency magnetic field exposure and selected cancer outcomes in a prospective Dutch cohort.

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  • Additional Information
    • Source:
      Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9100846 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7225 (Electronic) Linking ISSN: 09575243 NLM ISO Abbreviation: Cancer Causes Control Subsets: MEDLINE
    • Publication Information:
      Publication: Dordrecht : Kluwer Academic Publishers
      Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., 1990-
    • Subject Terms:
      Electromagnetic Fields*; Neoplasms/*epidemiology ; Occupational Diseases/*epidemiology ; Occupational Exposure/*statistics & numerical data; Aged ; Case-Control Studies ; Cohort Studies ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Neoplasms/etiology ; Netherlands/epidemiology ; Occupational Diseases/etiology ; Occupational Exposure/adverse effects ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Treatment Outcome
    • Abstract:
      Purpose: To investigate the association between exposure to occupational extremely low-frequency magnetic fields (ELF-MF) and the risk of a priori selected cancer outcomes within the prospective Netherlands Cohort Study.
      Methods: 120,852 men and women aged 55-69 years at time of enrollment in 1986 were followed up (17.3 years) for incident lung, breast and brain cancer, and hemato-lymphoproliferative malignancies. Information on occupational history and potential confounders such as sex, age, smoking, alcohol use, and attained educational level were collected at baseline through a self-administered questionnaire. Occupational ELF-MF exposure was assigned with a job-exposure matrix. Using a case-cohort approach, associations with cancer incidence were analyzed with Cox regression stratified by sex, using three exposure metrics: (1) ever had a job with low or high exposure to ELF-MF versus background, (2) duration of exposure, and (3) cumulative exposure.
      Results: None of the exposure metrics showed an effect on incidence for lung, breast, and brain cancer, nor any of the assessed subtypes in men and women. Of the hemato-lymphoproliferative malignancies in men, ever high exposed to ELF-MF showed a significant association with acute myeloid leukemia (AML) [hazard ratio (HR) 2.15; 95 % confidence interval (CI) 1.06-4.35] and follicular lymphoma (FL) (HR 2.78; 95 % CI 1.00-5.77). Cumulative exposure to ELF-MF showed a significant, positive association with FL but not AML among men.
      Conclusions: In this large prospective cohort study, we found some indications of an increased risk of AML and FL among men with occupational ELF-MF exposure. These findings warrant further investigation.
    • Publication Date:
      Date Created: 20131119 Date Completed: 20141022 Latest Revision: 20140124
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s10552-013-0322-x
    • Accession Number:
      24241907