Design and verification of a shape memory polymer peripheral occlusion device.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101322406 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0180 (Electronic) Linking ISSN: 18780180 NLM ISO Abbreviation: J Mech Behav Biomed Mater Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier
    • Subject Terms:
      Aneurysm/*therapy ; Embolization, Therapeutic/*instrumentation ; Polymers/*chemistry; Animals ; Biocompatible Materials ; Swine ; Transition Temperature
    • Abstract:
      Shape memory polymer foams have been previously investigated for their safety and efficacy in treating a porcine aneurysm model. Their biocompatibility, rapid thrombus formation, and ability for endovascular catheter-based delivery to a variety of vascular beds makes these foams ideal candidates for use in numerous embolic applications, particularly within the peripheral vasculature. This study sought to investigate the material properties, safety, and efficacy of a shape memory polymer peripheral embolization device in vitro. The material characteristics of the device were analyzed to show tunability of the glass transition temperature (Tg) and the expansion rate of the polymer to ensure adequate time to deliver the device through a catheter prior to excessive foam expansion. Mechanical analysis and flow migration studies were performed to ensure minimal risk of vessel perforation and undesired thromboembolism upon device deployment. The efficacy of the device was verified by performing blood flow studies that established affinity for thrombus formation and blood penetration throughout the foam and by delivery of the device in an ultrasound phantom that demonstrated flow stagnation and diversion of flow to collateral pathways.
      (Copyright © 2016 Elsevier Ltd. All rights reserved.)
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    • Grant Information:
      R01 EB000462 United States EB NIBIB NIH HHS; R43 EB022016 United States EB NIBIB NIH HHS; R44 EB022016 United States EB NIBIB NIH HHS
    • Contributed Indexing:
      Keywords: Embolization; Pelvic congestion syndrome; Shape memory polymer; Varicocele; Varicose veins
    • Accession Number:
      0 (Biocompatible Materials)
      0 (Polymers)
    • Publication Date:
      Date Created: 20160716 Date Completed: 20171206 Latest Revision: 20231112
    • Publication Date:
      20231112
    • Accession Number:
      PMC5508979
    • Accession Number:
      10.1016/j.jmbbm.2016.06.019
    • Accession Number:
      27419615