Congenital Malformations and Perinatal Deaths Among the Children of Atomic Bomb Survivors: A Reappraisal.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 7910653 Publication Model: Print Cited Medium: Internet ISSN: 1476-6256 (Electronic) Linking ISSN: 00029262 NLM ISO Abbreviation: Am J Epidemiol Subsets: MEDLINE
    • Publication Information:
      Publication: Cary, NC : Oxford University Press
      Original Publication: Baltimore, School of Hygiene and Public Health of Johns Hopkins Univ.
    • Subject Terms:
      Atomic Bomb Survivors/*statistics & numerical data ; Congenital Abnormalities/*epidemiology ; Pregnancy Outcome/*epidemiology; Adult ; Female ; Humans ; Infant, Newborn ; Japan/epidemiology ; Male ; Perinatal Mortality ; Pregnancy ; Radiation Dosage
    • Abstract:
      From 1948 to 1954, the Atomic Bomb Casualty Commission conducted a study of pregnancy outcomes among births to atomic bomb survivors (Hiroshima and Nagasaki, Japan) who had received radiation doses ranging from 0 Gy to near-lethal levels. Past reports (1956, 1981, and 1990) on the cohort did not identify significant associations of radiation exposure with untoward pregnancy outcomes, such as major congenital malformations, stillbirths, or neonatal deaths, individually or in aggregate. We reexamined the risk of major congenital malformations and perinatal deaths in the children of atomic bomb survivors (n = 71,603) using fully reconstructed data to minimize the potential for bias, using refined estimates of the gonadal dose from Dosimetry System 2002 and refined analytical methods for characterizing dose-response relationships. The analyses showed that parental exposure to radiation was associated with increased risk of major congenital malformations and perinatal death, but the estimates were imprecise for direct radiation effects, and most were not statistically significant. Nonetheless, the uniformly positive estimates for untoward pregnancy outcomes among children of both maternal and paternal survivors are useful for risk assessment purposes, although extending them to populations other than the atomic bomb survivors comes with uncertainty as to generalizability.
      (© The Author(s) 2021. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.)
    • Comments:
      Comment in: Am J Epidemiol. 2021 Nov 2;190(11):2337-2338. (PMID: 34023879)
      Comment in: Am J Epidemiol. 2021 Nov 2;190(11):2334-2336. (PMID: 34023897)
    • References:
      Radiat Res. 1990 Apr;122(1):1-11. (PMID: 2320718)
      Proc Natl Acad Sci U S A. 1977 Aug;74(8):3523-7. (PMID: 269410)
      Birth Defects Res A Clin Mol Teratol. 2015 Apr;103(4):243-54. (PMID: 25820072)
      Lancet Oncol. 2015 Oct;16(13):1316-23. (PMID: 26384241)
      Mutat Res. 2012 Apr 1;732(1-2):21-5. (PMID: 22289278)
      Health Phys. 2003 Jul;85(1):65-80. (PMID: 12852473)
      J Radiat Res. 2006;47 Suppl B:B67-73. (PMID: 17019054)
      J Radiol Prot. 2001 Jun;21(2):133-44. (PMID: 11430514)
      Radiat Res. 2006 Jul;166(1 Pt 2):219-54. (PMID: 16808610)
      Am J Hum Genet. 1966 Jul;18(4):339-73. (PMID: 17948513)
      Lancet. 2000 Oct 14;356(9238):1293-9. (PMID: 11073016)
      BJOG. 2014 Sep;121 Suppl 4:141-53. (PMID: 25236649)
      J Radiol Prot. 2013 Jun;33(2):281-93. (PMID: 23482396)
      Mutat Res. 2013 Jul-Sep;753(1):50-67. (PMID: 23648355)
      Occup Environ Med. 1996 Feb;53(2):73-9. (PMID: 8777454)
      Int J Environ Res Public Health. 2018 Jun 10;15(6):. (PMID: 29890768)
      Acta Genet Stat Med. 1956-1957;6(2):183-96. (PMID: 13410480)
      Pediatrics. 2004 Apr;113(4 Suppl):957-68. (PMID: 15060188)
      J Clin Oncol. 2012 Jan 1;30(1):27-33. (PMID: 22124106)
      Clin Genet. 2009 Jan;75(1):50-6. (PMID: 19021636)
      Leuk Lymphoma. 2018 Feb;59(2):381-397. (PMID: 28728448)
      Science. 1981 Sep 11;213(4513):1220-7. (PMID: 7268429)
      Am J Epidemiol. 1988 Feb;127(2):226-42. (PMID: 3276166)
      Lancet. 2010 Aug 21;376(9741):624-30. (PMID: 20655585)
      J Clin Oncol. 2012 Jan 20;30(3):239-45. (PMID: 22162566)
      Lancet. 1999 Oct 23;354(9188):1407-14. (PMID: 10543666)
      Am J Hum Genet. 1990 Jun;46(6):1053-72. (PMID: 2339701)
    • Contributed Indexing:
      Keywords: atomic bomb; congenital malformations; genetics; nuclear weapons; perinatal mortality; pregnancy outcomes; radiation effects
    • Publication Date:
      Date Created: 20210413 Date Completed: 20211112 Latest Revision: 20211112
    • Publication Date:
      20240829
    • Accession Number:
      PMC8561127
    • Accession Number:
      10.1093/aje/kwab099
    • Accession Number:
      33847738