Detection of Novel US Neisseria meningitidis Urethritis Clade Subtypes in Japan.

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  • Additional Information
    • Source:
      Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
    • Subject Terms:
      Neisseria meningitidis*/genetics ; Urethritis*/epidemiology ; Urethritis*/microbiology ; Sexual and Gender Minorities* ; Meningococcal Infections*/epidemiology ; Meningococcal Infections*/microbiology; Male ; Humans ; United States/epidemiology ; Homosexuality, Male ; Japan/epidemiology
    • Abstract:
      Neisseria meningitidis causes invasive meningococcal diseases and has also been identified as a causative agent of sexually transmitted infections, including urethritis. Unencapsulated sequence type 11 meningococci containing the gonococcal aniA-norB locus and belonging to the United States N. meningitidis urethritis clade (US_NmUC) are causative agents of urethral infections in the United States, predominantly among men who have sex with men. We identified 2 subtypes of unencapsulated sequence type 11 meningococci in Japan that were phylogenetically close to US_NmUC, designated as the Japan N. meningitidis urethritis clade (J_NmUC). The subtypes were characterized by PCR, serologic testing, and whole-genome sequencing. Our study suggests that an ancestor of US_NmUC and J_NmUS urethritis-associated meningococci is disseminated worldwide. Global monitoring of urethritis-associated N. meningitidis isolates should be performed to further characterize microbiologic and epidemiologic characteristics of urethritis clade meningococci.
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    • Grant Information:
      United Kingdom WT_ Wellcome Trust
    • Contributed Indexing:
      Keywords: Japan; Neisseria meningitidis; bacteria; invasive meningococcal diseases; meningitis/encephalitis; meningococci; phylogenetic analysis; serogroup; sexually transmitted infections; urethritis; urethritis clade; whole-genome sequencing
    • Publication Date:
      Date Created: 20231025 Date Completed: 20231026 Latest Revision: 20231205
    • Publication Date:
      20231205
    • Accession Number:
      PMC10617353
    • Accession Number:
      10.3201/eid2911.231082
    • Accession Number:
      37877502