Soybean Oil-Based 3D Printed Mesh Designed for Guided Bone Regeneration (GBR) in Oral Surgery.

Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101135941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1616-5195 (Electronic) Linking ISSN: 16165187 NLM ISO Abbreviation: Macromol Biosci Subsets: MEDLINE

Original Publication: Weinheim, Germany : Wiley-VCH, c2001-

Printing, Three-Dimensional* ; Bone Regeneration*/drug effects ; Soybean Oil*/chemistry; Humans ; Oral Surgical Procedures/methods ; Animals ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Guided Tissue Regeneration/methods ; Mice ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Cell Proliferation/drug effects

This study aims to obtain a cyto-compatible 3D printable bio-resin for the manufacturing of meshes designed from acquired real patients' bone defect to be used in future for guided bone regeneration (GBR), achieving the goal of personalized medicine, decreasing surgical, recovery time, and patient discomfort. To this purpose, a biobased, biocompatible, and photo-curable resin made of acrylated epoxidized soybean oil (AESO) diluted with soybean oil (SO) is developed and 3D printed using a commercial digital light processing (DLP) 3D printer. 3D printed samples show good thermal properties, allowing for thermally-based sterilization process and mechanical properties typical of crosslinked natural oils (i.e., E = 12 MPa, UTS = 1.5 MPa), suitable for the GBR application in the oral surgery. The AESO-SO bio-resin proves to be cytocompatible, allowing for fibroblast cells proliferation (viability at 72 h > 97%), without inducing severe inflammatory response when co-cultured with macrophages, as demonstrated by cytokine antibody arrays, that is anyway resolved in the first 24 h. Moreover, accelerated degradation tests prove that the bio-resin is biodegradable in hydrolytic environments.
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Keywords: 3D printing; acrylated epoxidized soybean oil; biodegradability; guided bone regeneration

Date Created: 20240110 Date Completed: 20240516 Latest Revision: 20240516

20240516

10.1002/mabi.202300458

38198834