Wearing the Lab: Advances and Challenges in Skin-Interfaced Systems for Continuous Biochemical Sensing.

Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8307733 Publication Model: Print Cited Medium: Print ISSN: 0724-6145 (Print) Linking ISSN: 07246145 NLM ISO Abbreviation: Adv Biochem Eng Biotechnol Subsets: MEDLINE

Publication: Heidelberg : Springer Verlag
Original Publication: Berlin ; New York : Springer-Verlag, [1983-

Biosensing Techniques*/methods ; Biosensing Techniques*/instrumentation ; Wearable Electronic Devices* ; Skin*/metabolism ; Skin*/chemistry; Humans ; Sweat/chemistry ; Equipment Design

Continuous, on-demand, and, most importantly, contextual data regarding individual biomarker concentrations exemplify the holy grail for personalized health and performance monitoring. This is well-illustrated for continuous glucose monitoring, which has drastically improved outcomes and quality of life for diabetic patients over the past 2 decades. Recent advances in wearable biosensing technologies (biorecognition elements, transduction mechanisms, materials, and integration schemes) have begun to make monitoring of other clinically relevant analytes a reality via minimally invasive skin-interfaced devices. However, several challenges concerning sensitivity, specificity, calibration, sensor longevity, and overall device lifetime must be addressed before these systems can be made commercially viable. In this chapter, a logical framework for developing a wearable skin-interfaced device for a desired application is proposed with careful consideration of the feasibility of monitoring certain analytes in sweat and interstitial fluid and the current development of the tools available to do so. Specifically, we focus on recent advancements in the engineering of biorecognition elements, the development of more robust signal transduction mechanisms, and novel integration schemes that allow for continuous quantitative analysis. Furthermore, we highlight the most compelling and promising prospects in the field of wearable biosensing and the challenges that remain in translating these technologies into useful products for disease management and for optimizing human performance.
(© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.)

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Keywords: Biosensing; Electrochemical; Interstitial fluid; Optical; Sweat; Wearables

Date Created: 20240125 Date Completed: 20240529 Latest Revision: 20240611

20240612

10.1007/10_2023_238

38273210