Obsessive-compulsive disorder in Chinese methamphetamine patients: Prevalence, demographics, and clinical characteristics.

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    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9208821 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0391 (Electronic) Linking ISSN: 10550496 NLM ISO Abbreviation: Am J Addict Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Wiley-Blackwell
      Original Publication: Washington, DC : American Psychiatric Press, c1992-
    • Subject Terms:
    • Abstract:
      Background and Objectives: Methamphetamine (MA) is one of the most common addictive substances and has become the second most commonly used drug worldwide. Obsessive-compulsive disorder (OCD) has been shown to influence the effectiveness of addiction treatment, and there may be overlapping neurobiological mechanisms between OCD and addiction. The aim of this study was to investigate the prevalence and clinical correlates of OCD among MA patients.
      Methods: A total of 457 MA patients were recruited, and clinical and demographic data were collected. The Yale-Brown Obsessive-Compulsive Scale was utilized for OCD symptoms, and the Obsessive-Compulsive Drug Use Scale was used for MA craving.
      Results: The prevalence of OCD among MA patients was 7.7%. Compared to those patients without OCD, patients with OCD had a longer length of abstinence and higher OCDUS frequency of craving subscale and total scores. Multiple regression showed that longer length of abstinence and higher MA carving were independently associated with OCD in MA patients.
      Discussion and Conclusions: Chinese Han MA patients have a high prevalence of OCD. Some clinical parameters may be associated with OCD in MA patients.
      Scientific Significance: This is the first study to examine the prevalence, sociodemographic and clinical correlates of OCD in MA patients in a Chinese Han population.
      (© 2022 The American Academy of Addiction Psychiatry (AAAP).)
    • References:
      Assi S, Gulyamova N, Ibrahim K, Kneller P, Osselton D. Profile, effects, and toxicity of novel psychoactive substances: a systematic review of quantitative studies. Hum Psychopharmacol Clin Exp. 2017;32(3):e2607.
      Martinotti G, Lupi M, Carlucci L, et al. Novel psychoactive substances: use and knowledge among adolescents and young adults in urban and rural areas. Hum Psychopharmacol Clin Exp. 2015;30(4):295-301.
      Zhang C, Luo T, Liu L, Dong H, Hao W. Prevalence rates of personality disorder and its association with methamphetamine dependence in compulsory treatment facilities in China. Front Psychiatry. 2018;9:698.
      Cretzmeyer M, Sarrazin MV, Huber DL, Block RI, Hall JA. Treatment of methamphetamine abuse: research findings and clinical directions. J Subst Abuse Treat. 2003;24(3):267-277.
      Fals-Stewart W, Schafer J. The treatment of substance abusers diagnosed with obsessive-compulsive disorder: an outcome study. J Subst Abuse Treat. 1992;9(4):365-370.
      Pérez-Vigil A, Fernández de la Cruz L, Brander G, et al. Association of obsessive-compulsive disorder with objective indicators of educational attainment: a nationwide register-based sibling control study. JAMA Psychiatry. 2018;75(1):47-55.
      Kayser RR, Senter MS, Tobet R, Raskin M, Patel S, Simpson HB. Patterns of cannabis use among individuals with obsessive-compulsive disorder: results from an Internet survey. J Obsessive Compuls Relat Disord. 2021;30:100664.
      Figee M, Pattij T, Willuhn I, et al. Compulsivity in obsessive-compulsive disorder and addictions. Eur Neuropsychopharmacol. 2016;26(5):856-868.
      Brander G, Pérez-Vigil A, Larsson H, Mataix-Cols D. Systematic review of environmental risk factors for obsessive-compulsive disorder: a proposed roadmap from association to causation. Neurosci Biobehav Rev. 2016;65:36-62.
      Rowe C, Deledalle A, Boudoukha AH. Psychiatric comorbidities of obsessive-compulsive disorder: a series of systematic reviews and meta-analyses. J Clin Psychol. 2021;78(4):469-484.
      Mancebo MC, Grant JE, Pinto A, Eisen JL, Rasmussen SA. Substance use disorders in an obsessive compulsive disorder clinical sample. J Anxiety Disord. 2009;23(4):429-435.
      Shakeri J, Farnia V, Karimi AR, et al. The prevalence and clinical features of amphetamine-induced obsessive compulsive disorder. Drug Alcohol Depend. 2016;160:157-162.
      Semple SJ, Strathdee SA, Zians J, McQuaid J, Patterson TL. Correlates of obsessive-compulsive disorder in a sample of HIV-positive, methamphetamine-using men who have sex with men. AIDS Behav. 2011;15(6):1153-1160.
      Wootton B, Tolin DF. Obsessive-compulsive disorder. In: Friedman HS, ed., Encyclopedia of mental health. Elsevier Academic Press; 2016.
      Yang C, Wei W, Vrana KE, et al. Validation of the obsessive compulsive drug use scale (OCDUS) among male heroin addicts in China. Int J Ment Health Addict. 2016;14(5):803-819.
      IBM Corp. IBM SPSS statistics for windows, version 26.0. IBM Corp; 2019.
      Crum RM, Anthony JC. Cocaine use and other suspected risk factors for obsessive-compulsive disorder: a prospective study with data from the epidemiologic catchment area surveys. Drug Alcohol Depend. 1993;31(3):281-295.
      Fontenelle LF, Oostermeijer S, Harrison BJ, Pantelis C, Yücel M. Obsessive-compulsive disorder, impulse control disorders and drug addiction. Drugs. 2011;71(7):827-840.
      Dean AC, Groman SM, Morales AM, London ED. An evaluation of the evidence that methamphetamine abuse causes cognitive decline in humans. Neuropsychopharmacology. 2013;38(2):259-274.
      Iudicello JE, Woods SP, Vigil O, et al. Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence. J Clin Exp Neuropsychol. 2010;32(7):704-718.
      Proebstl L, Krause D, Kamp F, et al. Methamphetamine withdrawal and the restoration of cognitive functions-a study over a course of 6 months abstinence. Psychiatry Res. 2019;281:112599.
      Wang G, Shi J, Chen N, et al. Effects of length of abstinence on decision-making and craving in methamphetamine abusers. PLoS One. 2013;8(7):e68791.
      Altshuler RD, Lin H, Li X. Neural mechanisms underlying incubation of methamphetamine craving: a mini-review. Pharmacol Biochem Behav. 2020;199:173058.
      Zorick T, Nestor L, Miotto K, et al. Withdrawal symptoms in abstinent methamphetamine-dependent subjects. Addiction. 2010;105(10):1809-1818.
      Nakama H, Chang L, Cloak C, Jiang C, Alicata D, Haning W. Association between psychiatric symptoms and craving in methamphetamine users. Am J Addict. 2008;17(5):441-446.
      Anton RF. Obsessive-compulsive aspects of craving: development of the obsessive compulsive drinking scale. Addiction. 2000;95(8s2):211-217.
    • Accession Number:
      44RAL3456C (Methamphetamine)
    • Publication Date:
      Date Created: 20221212 Date Completed: 20230424 Latest Revision: 20230513
    • Publication Date:
      20240829
    • Accession Number:
      10.1111/ajad.13367
    • Accession Number:
      36504235