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Publication : journal of clinical investigation Subject : cell biology Subject : clinical medicine Subject : oncology Filter by : Subject Phrase

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Academic Journal

Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment.

Authors : Araujo, Angela M.; Abaurrea, Andrea; Azcoaga, Peio

Subjects: CYTOKINES; FIBROBLASTS; CELL physiology

Source: Journal of Clinical Investigation. Apr2022, Vol. 132 Issue 7, p1-17. 17p.

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Academic Journal

ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine.

Authors : Jun Xu; Sek Man Su; Xin Zhang

Subjects: METASTATIC breast cancer; PHOSPHATIDYLSERINES; PACLITAXEL

Source: Journal of Clinical Investigation. Mar2022, Vol. 132 Issue 5, p1-19. 19p.

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Academic Journal

RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.

Authors : Zhiying Yue; Xin Niu; Zengjin Yuan

Subjects: BONE metastasis; TRANCE protein; LOW density lipoprotein receptors

Source: Journal of Clinical Investigation. 1/18/2022, Vol. 132 Issue 2, p1-19. 19p.

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Academic Journal

Breast cancer-derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment.

Authors : Xinming Su; Yalin Xu; Fox, Gregory C.

Subjects: MYELOID cells; GRANULOCYTE-macrophage colony-stimulating factor; ARGINASE

Source: Journal of Clinical Investigation. 10/15/2021, Vol. 131 Issue 20, p1-17. 17p.

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Academic Journal

FOXA1 overexpression suppresses interferon signaling and immune response in cancer.

Authors : Yundong He; Liguo Wang; Ting Wei

Subjects: BLADDER cancer; INTERFERON gamma; PROGNOSIS

Source: Journal of Clinical Investigation. 7/15/2021, Vol. 131 Issue 14, p1-17. 17p.

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Academic Journal

Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models.

Authors : Mehibel, Manal; Yu Xu; Li, Caiyun G.

Subjects: POLY(ADP-ribose) polymerase; BREAST cancer; DNA damage

Source: Journal of Clinical Investigation. 6/1/2021, Vol. 131 Issue 11, p1-17. 17p.

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Academic Journal

Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones.

Authors : Karthikeyan, Swathi; Waters, Ian G.; Dennison, Lauren

Subjects: HORMONE receptor positive breast cancer; HETEROGENEITY; INDIVIDUALIZED medicine

Source: Journal of Clinical Investigation. 3/15/2021, Vol. 131 Issue 6, p1-10. 10p.

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Academic Journal

Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control.

Authors : Lhuillier, Claire; Rudqvist, Nils-Petter; Takahiro Yamazaki

Subjects: TRIPLE-negative breast cancer; T cells; DEATH receptors

Source: Journal of Clinical Investigation. Mar2021, Vol. 131 Issue 5, p1-18. 19p.

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Academic Journal

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.

Authors : Edwards, Deanna N.; Ngwa, Verra M.; Raybuck, Ariel L.

Subjects: GLUTAMINE; TRIPLE-negative breast cancer; T cells

Source: Journal of Clinical Investigation. 2/15/2021, Vol. 131 Issue 4, p1-16. 16p.

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Academic Journal

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.

Authors : Patel, Parasvi S.; Abraham, Karan Joshua; Naidu Guturi, Kiran Kumar

Subjects: UBIQUITIN ligases; DOUBLE-strand DNA breaks; GENES

Source: Journal of Clinical Investigation. 2/1/2021, Vol. 131 Issue 3, p1-14. 14p.

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