Mutations in the basal core promoter and precore/core gene of hepatitis B virus in patients with chronic active but not acute hepatitis B.

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  • Author(s): Mayerat C;Mayerat C; Mantegani A; Spertini F; Frei PC
  • Source:
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 1999 Dec; Vol. 18 (12), pp. 871-8.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print Cited Medium: Print ISSN: 0934-9723 (Print) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer
      Original Publication: [Wiesbaden, Federal Republic of Germany] : Vieweg, [c1988-
    • Subject Terms:
      Mutation*; Hepatitis B virus/*genetics ; Hepatitis B, Chronic/*virology ; Promoter Regions, Genetic/*genetics ; Viral Core Proteins/*genetics; Acute Disease ; Adult ; Amino Acid Sequence ; Base Sequence ; DNA, Viral/genetics ; Female ; Hepatitis B/virology ; Humans ; Male ; Molecular Sequence Data ; Sequence Analysis, DNA
    • Abstract:
      Around 5-10% of adults infected with hepatitis B virus (HBV) develop a chronic liver disease such as chronic active hepatitis (CAH), and it is unclear whether the clinical outcome depends solely on the immune response or whether viral factors also play a role. In this study, a search was therefore made for nucleotide mutations in the basic core promoter (BCP) and amino-acid substitutions in the precore/core region of HBV infecting patients with CAH or with acute hepatitis. The nucleotide sequences of the BCP and of the precore/core region were determined in virus from ten patients with CAH and ten with acute hepatitis. The precore/core sequences were also analysed in 14 additional patients (6 with CAH, 8 with acute hepatitis). In seven of the ten patients with CAH, five types of mutations were found in the BCP. Deletions in the precore/core region were observed in six patients. In all six patients where only the precore/core region was studied, amino-acid substitutions were present. In contrast, in the ten patients with acute hepatitis studied for BCP, a mutation was found in the BCP of one patient only. Of the 18 patients in whom the precore/core was studied, three had an amino-acid substitution in this region. The results show a clear link between CAH and both HBV BCP and precore/core region mutations, suggesting these mutations may play a role in the persistence of HBV infection.
    • Accession Number:
      0 (DNA, Viral)
      0 (Viral Core Proteins)
    • Publication Date:
      Date Created: 20000226 Date Completed: 20000314 Latest Revision: 20190831
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s100960050422
    • Accession Number:
      10691198