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Folly Beach Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Main Library
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Phone: (843) 805-6930
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
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9 a.m. - 7 p.m.
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BreathDx - molecular analysis of exhaled breath as a diagnostic test for ventilator-associated pneumonia: protocol for a European multicentre observational study.
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- Author(s): van Oort, Pouline M. P.; Nijsen, Tamara; Weda, Hans; Knobel, Hugo; Dark, Paul; Felton, Timothy; Rattray, Nicholas J. W.; Lawal, Oluwasola; Ahmed, Waqar; Portsmouth, Craig; Sterk, Peter J.; Schultz, Marcus J.; Zakharkina, Tetyana; Artigas, Antonio; Povoa, Pedro; Martin-Loeches, Ignacio; Fowler, Stephen J.; Bos, Lieuwe D. J.; BreathDx Consortium
- Source:
BMC Pulmonary Medicine; 1/3/2017, Vol. 17, p1-8, 8p, 1 Color Photograph, 1 Diagram- Subject Terms:
VENTILATOR-associated pneumonia; PNEUMONIA diagnosis; VOLATILE organic compounds; MICROBIAL metabolism; MICROBIAL physiology; THERMAL desorption; ORGANIC compound analysis; ACADEMIC medical centers; BIOCHEMISTRY; BODY fluids; BREATH tests; COMPARATIVE studies; EXPERIMENTAL design; GAS chromatography; INTENSIVE care units; LONGITUDINAL method; MASS spectrometry; RESEARCH methodology; MEDICAL cooperation; RESEARCH; LOGISTIC regression analysis; EVALUATION research; DIAGNOSIS - Source:
- Additional Information
- Subject Terms:
- Abstract:
Background: The diagnosis of ventilator-associated pneumonia (VAP) remains time-consuming and costly, the clinical tools lack specificity and a bedside test to exclude infection in suspected patients is unavailable. Breath contains hundreds to thousands of volatile organic compounds (VOCs) that result from host and microbial metabolism as well as the environment. The present study aims to use breath VOC analysis to develop a model that can discriminate between patients who have positive cultures and who have negative cultures with a high sensitivity.Methods/design: The Molecular Analysis of Exhaled Breath as Diagnostic Test for Ventilator-Associated Pneumonia (BreathDx) study is a multicentre observational study. Breath and bronchial lavage samples will be collected from 100 and 53 intubated and ventilated patients suspected of VAP. Breath will be analysed using Thermal Desorption - Gas Chromatography - Mass Spectrometry (TD-GC-MS). The primary endpoint is the accuracy of cross-validated prediction for positive respiratory cultures in patients that are suspected of VAP, with a sensitivity of at least 99% (high negative predictive value).Discussion: To our knowledge, BreathDx is the first study powered to investigate whether molecular analysis of breath can be used to classify suspected VAP patients with and without positive microbiological cultures with 99% sensitivity.Trial Registration: UKCRN ID number 19086, registered May 2015; as well as registration at www.trialregister.nl under the acronym 'BreathDx' with trial ID number NTR 6114 (retrospectively registered on 28 October 2016). [ABSTRACT FROM AUTHOR] - Abstract: Copyright of BMC Pulmonary Medicine is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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