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Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
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John's Island Library
9 a.m. - 8 p.m.
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Otranto Road Library
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9 p.m. - 8 p.m.
Phone: (843) 805-6892
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9 a.m. - 6 p.m.
Phone: (843) 884-9741
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Phone: (843) 805-6909
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Effect of induction therapy on circulating T-helper 17 and T-regulatory cells in active proliferative lupus nephritis.
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- Author(s): Shenoy, Sajjan; Chaurasia, Smriti; Edavalath, Sukesh; Zanwar, Abhishek; Agrawal, Vinita; Aggarwal, Amita; Misra, Ramnath
- Source:
International Journal of Rheumatic Diseases; May2018, Vol. 21 Issue 5, p1040-1048, 9p- Subject Terms:
- Source:
- Additional Information
- Abstract: Introduction: T-helper 17 (Th17) cells and T-regulatory (Treg) cells have been suggested to play pathogenic roles in lupus nephritis. The in vivo effects of current therapies for lupus nephritis (LN) on these cells have not been adequately studied. Methods: We conducted a prospective observational study among patients with active proliferative lupus nephritis (LN) who received Eurolupus induction therapy and assessed them as per the European League Against Rheumatism criteria for renal response. Peripheral circulatory Th17 and Treg cell numbers were enumerated at start of therapy, at 3 and 6 months follow-up periods using flow cytometry. Baseline values were compared with inactive lupus patients (iSLE) and healthy controls (HC). Results: Thirty patients with LN, 20 iSLE and 22 HC were enrolled into the study. In LN, Th17 frequency was significantly higher compared to HC, and Treg frequency significantly lower compared to both iSLE and HC. Nineteen patients fulfilled criteria for response (partial or complete) at 6 months. Responder group showed a significant decline in Th17 frequency and an increasing trend in Treg frequency compared to baseline after 6 months of therapy. Conclusion: Circulating Th17 cells were significantly raised in patients with active proliferative LN and showed a significant reduction in responder patients following therapy. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of International Journal of Rheumatic Diseases is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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