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Wando Mount Pleasant Library
Closed
Phone: (843) 805-6888
Main Library
2 p.m. – 5 p.m.
Phone: (843) 805-6930
McClellanville Library
Closed
Phone: (843) 887-3699
Folly Beach Library
Closed
Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
Closed for renovations
Phone: (843) 869-2355
West Ashley Library
Closed
Phone: (843) 766-6635
John L. Dart Library
Closed
Phone: (843) 722-7550
St. Paul's/Hollywood Library
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Phone: (843) 889-3300
Mt. Pleasant Library
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Phone: (843) 849-6161
Dorchester Road Library
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Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
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John's Island Library
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Phone: (843) 559-1945
Otranto Road Library
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Phone: (843) 572-4094
Hurd/St. Andrews Library
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Phone: (843) 766-2546
Baxter-Patrick James Island
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Phone: (843) 795-6679
Bees Ferry West Ashley Library
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Phone: (843) 805-6892
Village Library
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Phone: (843) 884-9741
Keith Summey North Charleston Library
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Phone: (843) 744-2489
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The effect of amantadine on an ion channel protein from Chikungunya virus.
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- Author(s): Dey, Debajit; Siddiqui, Shumaila Iqbal; Mamidi, Prabhudutta; Ghosh, Sukanya; Kumar, Chandra Shekhar; Chattopadhyay, Soma; Ghosh, Subhendu; Banerjee, Manidipa
- Source:
PLoS Neglected Tropical Diseases; 7/24/2019, Vol. 13 Issue 7, p1-22, 22p- Subject Terms:
- Source:
- Additional Information
- Abstract: Viroporins like influenza A virus M2, hepatitis C virus p7, HIV-1 Vpu and picornavirus 2B associate with host membranes, and create hydrophilic corridors, which are critical for viral entry, replication and egress. The 6K proteins from alphaviruses are conjectured to be viroporins, essential during egress of progeny viruses from host membranes, although the analogue in Chikungunya Virus (CHIKV) remains relatively uncharacterized. Using a combination of electrophysiology, confocal and electron microscopy, and molecular dynamics simulations we show for the first time that CHIKV 6K is an ion channel forming protein that primarily associates with endoplasmic reticulum (ER) membranes. The ion channel activity of 6K can be inhibited by amantadine, an antiviral developed against the M2 protein of Influenza A virus; and CHIKV infection of cultured cells can be effectively inhibited in presence of this drug. Our study provides crucial mechanistic insights into the functionality of 6K during CHIKV-host interaction and suggests that 6K is a potential therapeutic drug target, with amantadine and its derivatives being strong candidates for further development. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of PLoS Neglected Tropical Diseases is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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