Menu
×
McClellanville Library
Closed (2024 - Memorial Day)
Phone: (843) 887-3699
Folly Beach Library
Closed (2024 - Memorial Day)
Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
Closed (2024 - Memorial Day)
Phone: (843) 869-2355
Main Library
Closed (2024 - Memorial Day)
Phone: (843) 805-6930
West Ashley Library
Closed (2024 - Memorial Day)
Phone: (843) 766-6635
John L. Dart Library
Closed (2024 - Memorial Day)
Phone: (843) 722-7550
St. Paul's/Hollywood Library
Closed (2024 - Memorial Day)
Phone: (843) 889-3300
Mt. Pleasant Library
Closed (2024 - Memorial Day)
Phone: (843) 849-6161
Dorchester Road Library
Closed (2024 - Memorial Day)
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
Closed (2024 - Memorial Day)
Phone: (843) 883-3914
John's Island Library
Closed (2024 - Memorial Day)
Phone: (843) 559-1945
Wando Mount Pleasant Library
Closed (2024 - Memorial Day)
Phone: (843) 805-6888
Otranto Road Library
Closed (2024 - Memorial Day)
Phone: (843) 572-4094
Hurd/St. Andrews Library
Closed (2024 - Memorial Day)
Phone: (843) 766-2546
Baxter-Patrick James Island
Closed (2024 - Memorial Day)
Phone: (843) 795-6679
Bees Ferry West Ashley Library
Closed (2024 - Memorial Day)
Phone: (843) 805-6892
Village Library
Closed (2024 - Memorial Day)
Phone: (843) 884-9741
Keith Summey North Charleston Library
Closed (2024 - Memorial Day)
Phone: (843) 744-2489
Mobile Library
Closed (2024 - Memorial Day)
Phone: (843) 805-6909
Today's Hours
McClellanville Library
Closed (2024 - Memorial Day)
Phone: (843) 887-3699
Folly Beach Library
Closed (2024 - Memorial Day)
Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
Closed (2024 - Memorial Day)
Phone: (843) 869-2355
Main Library
Closed (2024 - Memorial Day)
Phone: (843) 805-6930
West Ashley Library
Closed (2024 - Memorial Day)
Phone: (843) 766-6635
John L. Dart Library
Closed (2024 - Memorial Day)
Phone: (843) 722-7550
St. Paul's/Hollywood Library
Closed (2024 - Memorial Day)
Phone: (843) 889-3300
Mt. Pleasant Library
Closed (2024 - Memorial Day)
Phone: (843) 849-6161
Dorchester Road Library
Closed (2024 - Memorial Day)
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
Closed (2024 - Memorial Day)
Phone: (843) 883-3914
John's Island Library
Closed (2024 - Memorial Day)
Phone: (843) 559-1945
Wando Mount Pleasant Library
Closed (2024 - Memorial Day)
Phone: (843) 805-6888
Otranto Road Library
Closed (2024 - Memorial Day)
Phone: (843) 572-4094
Hurd/St. Andrews Library
Closed (2024 - Memorial Day)
Phone: (843) 766-2546
Baxter-Patrick James Island
Closed (2024 - Memorial Day)
Phone: (843) 795-6679
Bees Ferry West Ashley Library
Closed (2024 - Memorial Day)
Phone: (843) 805-6892
Village Library
Closed (2024 - Memorial Day)
Phone: (843) 884-9741
Keith Summey North Charleston Library
Closed (2024 - Memorial Day)
Phone: (843) 744-2489
Mobile Library
Closed (2024 - Memorial Day)
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Author(s): Harari, Florencia; Barregard, Lars; Östling, Gerd; Sallsten, Gerd; Hedblad, Bo; Forsgard, Niklas; Yan Borné; Fagerberg, Björn; Engström, Gunnar
- Source:
Environmental Health Perspectives. Dec2019, Vol. 127 Issue 12, p127002-1-127002-10. 10p. 1 Diagram, 3 Charts, 2 Graphs. - Source:
- Additional Information
- Subject Terms: ATHEROSCLEROSIS risk factors; ATHEROSCLEROSIS; BIOMARKERS; BLOOD pressure; BODY weight; C-reactive protein; CARDIOVASCULAR diseases risk factors; CAROTID artery; CONFIDENCE intervals; ALCOHOL drinking; GLYCOSYLATED hemoglobin; HIGH density lipoproteins; HYPERTENSION; LEAD poisoning; LONGITUDINAL method; MASS spectrometry; STATURE; TRIGLYCERIDES; ULTRASONIC imaging; LOGISTIC regression analysis; ENVIRONMENTAL exposure; EDUCATIONAL attainment; BODY mass index; CROSS-sectional method; POSTMENOPAUSE; PHYSICAL activity; DATA analysis software; WAIST circumference; DESCRIPTIVE statistics; ODDS ratio
- Subject Terms:
- Abstract: BACKGROUND: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes. Atherosclerosis has been suggested as one of the underlying mechanisms, and findings from experimental studies support this, but human data are scarce. OBJECTIVES: Our objective was to determine the association between environmental lead exposure based on blood lead (B-Pb) concentrations and the prevalence of atherosclerotic plaque in the carotid artery. METHODS: We used cross-sectional data from the Malmö Diet and Cancer Study cardiovascular cohort (MDCS-CC; recruitment in 1991-1994) covering 4,172 middle-aged men and women. B-Pb at baseline, measured by inductively coupled plasma mass spectrometry, was used as the exposure biomarker. The presence of atherosclerotic plaque in the carotid artery was determined by B-mode ultrasonography. We used logistic regression to estimate odds ratios (ORs) for prevalence of plaque in the carotid artery according to B-Pb quartiles. RESULTS: The median B-Pb was 25μg/L (range: 1.5-258), and 36% of the cohort had any atherosclerotic plaque. After controlling for confounders and known cardiovascular risk factors, the OR for prevalence of plaque in the highest quartile (Q4) of B-Pb compared with the lowest quartile (Q1) was 1.35 (95% CI: 1.09, 1.66) in the total group, 1.58 (95% CI: 1.20, 2.08) among women, and 1.18 (95% CI: 0.83, 1.69) among men. Among women, associations were limited to those who were postmenopausal [OR for Q4 vs. Q1 = 1.72 (95% CI: 1.26, 2.34) vs. OR=0.96 (95% CI: 0.49, 1.89 in premenopausal women)]. Associations were weak and nonsignificant in never-smokers [OR for Q4 vs. Q1=1.14 (95% CI: 0.81, 1.61)]. DISCUSSION: Our study shows an association between B-Pb concentrations and occurrence of atherosclerotic plaque in the carotid artery, adding evidence for an underlying pro-atherogenic role of lead in cardiovascular disease. Associations appeared to be limited to postmenopausal (vs. premenopausal) women. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Subject Terms:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.