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McClellanville Library
9 a.m. – 1 p.m.
Phone: (843) 887-3699
Folly Beach Library
9 a.m. - 2 p.m.
Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
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Main Library
9 a.m. - 5 p.m.
Phone: (843) 805-6930
West Ashley Library
9 a.m. - 5 p.m.
Phone: (843) 766-6635
John L. Dart Library
9 a.m. - 5 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
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Phone: (843) 889-3300
Mt. Pleasant Library
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Dorchester Road Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Is glutamate associated with fear extinction and cognitive behavior therapy outcome in OCD? A pilot study.
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- Author(s): Giménez, M. (AUTHOR); Cano, M. (AUTHOR); Martínez-Zalacaín, I. (AUTHOR); Real, E. (AUTHOR); Alonso, P. (AUTHOR); Segalàs, C. (AUTHOR); Munuera, J. (AUTHOR); Kegeles, L. S. (AUTHOR); Weinstein, J. J. (AUTHOR); Xu, X. (AUTHOR); Menchón, J. M. (AUTHOR); Cardoner, N. (AUTHOR); Soriano-Mas, C. (AUTHOR); Fullana, M. A. (AUTHOR)
- Source:
European Archives of Psychiatry & Clinical Neuroscience. Dec2020, Vol. 270 Issue 8, p1003-1014. 12p. 1 Color Photograph, 1 Chart, 2 Graphs. - Source:
- Additional Information
- Subject Terms:
- Abstract: Cognitive behavioral therapy (CBT) including exposure and response prevention is a well-established treatment for obsessive–compulsive disorder (OCD) and is based on the principles of fear extinction. Fear extinction is linked to structural and functional variability in the ventromedial prefrontal cortex (vmPFC) and has been consistently associated with glutamate neurotransmission. The relationship between vmPFC glutamate and fear extinction and its effects on CBT outcome have not yet been explored in adults with OCD. We assessed glutamate levels in the vmPFC using 3T magnetic resonance spectroscopy, and fear extinction (learning and recall) using skin conductance responses during a 2-day experimental paradigm in OCD patients (n = 17) and in healthy controls (HC; n = 13). Obsessive–compulsive patients (n = 12) then received manualized CBT. Glutamate in the vmPFC was negatively associated with fear extinction recall and positively associated with CBT outcome (with higher glutamate levels predicting a better outcome) in OCD patients. Glutamate levels in the vmPFC in OCD patients were not significantly different from those in HC, and were not associated with OCD severity. Our results suggest that glutamate in the vmPFC is associated with fear extinction recall and CBT outcome in adult OCD patients. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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