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Folly Beach Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Main Library
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West Ashley Library
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Mycophenolate mofetil as treatment for lupus nephritis.
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- Author(s): Tak Mao Chan
- Source:
APLAR Journal of Rheumatology; Nov2004, Vol. 7 Issue 3, p268-271, 4p- Subject Terms:
- Source:
- Additional Information
- Abstract: Advances in immunosuppressive treatment and supportive care over the past few decades have led to improved clinical outcomes in patients with severe lupus nephritis. The management of severe proliferative lupus nephritis can be divided into an initial induction phase followed by a prolonged maintenance phase. Combined use of corticosteroid and cyclophosphamide has been the standard induction therapy, although a significant proportion of patients develop treatment-related complications such as infection and gonadal failure. While there is general agreement on the immunosuppressive regimen for induction treatment, there is marked variation with regard to maintenance immunosuppressive regimens. The latter is consequent to a paucity of data, since a big sample size and prolonged follow-up is required for clinical studies that investigate maintenance treatment, in view of the marked heterogeneity in patient characteristics and individual differences in the propensity for relapse. Nevertheless, there is accumulating evidence that a combination of corticosteroid and mycophenolate mofetil can be adopted as effective and well-tolerated treatment both for induction and for long-term maintenance in lupus nephritis. Favourable long-term prognosis can be ensured provided that effective treatment can be instituted early, before irreversible renal parenchymal damage is established. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of APLAR Journal of Rheumatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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