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Folly Beach Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Main Library
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West Ashley Library
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St. Paul's/Hollywood Library
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Mt. Pleasant Library
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Dorchester Road Library
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Edgar Allan Poe/Sullivan's Island Library
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John's Island Library
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Wando Mount Pleasant Library
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Phone: (843) 884-9741
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Necrotizing enterocolitis and mortality after transfusion of ABO non‐identical blood.
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- Author(s): Parvizian, Michael K.; Barty, Rebecca; Heddle, Nancy M.; Li, Na; McDougall, Tara; Mukerji, Amit; Fusch, Christoph; Solh, Ziad
- Source:
Transfusion; Nov2021, Vol. 61 Issue 11, p3094-3103, 10p- Subject Terms:
- Source:
- Additional Information
- Abstract: Background: The relationship between ABO non‐identical transfusion and the outcomes of necrotizing enterocolitis (NEC), and all‐cause mortality in very‐low birth weight (VLBW) neonates receiving red blood cell transfusion is unknown. Study design and methods: A retrospective multicenter cohort study was conducted in VLBW neonates in neonatal intensive care units between 2004 and 2016. VLBW (≤1500 grams) neonates were followed until discharge or in‐hospital death. The primary exposure was ABO group. Secondary exposures included platelet count, plasma transfusions, and maternal ABO group. Outcome measures were NEC (defined as Bell stage ≥ 2) and all‐cause mortality. Time‐dependent Cox regression models with competing risks were used to investigate factors associated with NEC and mortality. Results: Thousand and sixteen neonates were included with 10.8% developing NEC (n = 110) and 14.1% mortality (n = 143). Platelet count (hazard ratio [HR] = 0.995; 95% confidence interval [CI]: 0.922–0.998) and number of plasma transfusions (HR = 2.908; 95% CI:1.265–6.682) were associated with NEC, while ABO group (non‐O vs. O) was not (HR = 0.761; 95% CI: 0.393–1.471). Higher all‐cause mortality occurred in neonates without NEC who were non‐O compared with O (HR = 17.5; 95% CI: 1.784–171.692), but not in neonates with NEC (HR = 1.112; 95% CI: 0.142–8.841). Plasma transfusion was associated with increased mortality in both groups. Discussion: ABO non‐identical transfusion was not associated with NEC or mortality in neonates with NEC. It was associated with increased mortality in neonates without NEC. As many neonatal intensive care units transfuse only O group blood as routine practice, future trials are needed to investigate the association between this practice and neonatal mortality. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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