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بررسی علایم بالینی و آزمایشگاهی کودکان مبتلا به آرتریت ایدیوپاتیک جوانان تحت درمان با پالس متیل پردنیزولون. (Arabic)
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- Author(s): سید رضا رئیسکرمی; مایا قشقاییمنصو&; یحیی عقیقی; مامکشریعت
- Source:
Tehran University Medical Journal; Jul2022, Vol. 80 Issue 4, p275-285, 11p - Source:
- Additional Information
- Alternate Title: Evaluation of clinical and laboratory symptoms of children with idiopathic arthritis treated with methylprednisolone pulse. (English)
- Abstract: Background: Juvenile idiopathic arthritis is the most common rheumatic disease in children, which includes a group of disorders that all have a common clinical manifestation of arthritis. The aim of this study was evaluation of the clinical and laboratory symptoms of children with idiopathic arthritis who treated with intravenous methylprednisolone pulse. Methods: This study is a descriptive cross-sectional study of 20 years in Imam Khomeini Hospital from 1993 to 2013. Information of 202 hospitalized patients diagnosed with JIA who had files, containing demographic, clinical and laboratory data were recorded. The software 17spss was used for data statistically analyzed. Results: The mean age of patients was 6.98±3.65 years. After treatment in all age and sex groups, the mean of Hb and HCT increased significantly and WBC and PLT decreased significantly. Mean CRP and ESR decreased significantly. Mean alkaline phosphatase was significantly reduced in boys. There were no significant changes in AST and ALT. At Ca and K levels, the decrease was significant. There was significant increase in Na. Ca level in boys and K level in girls decreased and Na level in boys increased significantly. Serum sodium also increased significantly in the group over ten years, potassium in the group of five to ten years and calcium in the group up to 5 years and over ten years decreased significantly. FBS did not change significantly. Blood pressure increased significantly. In this study, the highest joint involvement related to knee joint that was 89.7% and the lowest joint involvement related to neck joint that was 7.4%, which ultimately improved significantly By 76.7% in response to treatment. Conclusion: Due to its availability, improving patient function and reducing clinical symptoms, this treatment is recommended. However, the need for further studies and consultation of other specialists, including cardiovascular counseling, seems necessary. [ABSTRACT FROM AUTHOR]
- Abstract: مينه و هدف: آرتریت ایدیوپاتیک جوانان شایعترین بیماری روماتولوژی در اطفال، شامل یک گروه از اختلالات که همگی دارای تظاهر بالینی مشترک آرتریت هستند. هدف بررسی علایم بالینی و آزمایشگاهی کودکان مبتلا به آرتریت ایدیوپاتیک جوانان درمان شده با پالس وریدی متیل پردنیزولون بوده است. روش بررسي: این مطالعه، یک پژوهش توصیفی- مقطعی 21 ساله از سال 1۷۳2 الی 1۷62 میباشدد. اطلاعدات 212 که پروندهای شامل دادههای دموگرافیک )جنس و سن(، دادههای بالینی و آزمایشگاهی JIA بیمار بستری با تشخیص تحلیل شد. SPSS software, version 17 (IBM SPSS, Armonk, NY, USA) داشتند ثبت گردید و توسط و HB 6 سال بود. پس از درمان در تمام گروههای سد نی و جنسد ی میدانگین /61±۷/ يافتهها: میانگین سنی بیماران 65 کاهش معنادار داشت. ESR و CRP بهطور معنادار کاهش داشت. میانگین PLT و WBC بهطور معنادار افزایش و HCT ،K و Ca تغییرات معنادارنبود. در سطح ALT و AST میانگین آلکالن فسفاتاز در گروه پسران کاهش معنادار داشت. در در پسران Na در دختران کاهش معنادار و K در پسران و Ca افزایش معنادار بود. سطح Na کاهش معناداربود. در میزان دارای افزایش معنادار بود. سدیم سرم در گروه سنی بالای 11 سال افزایش معنادار داشت، پتاسیم در گروه سنی پدن تغیید ر معند ادار نداشدت. FBS . تا 11 سال و کلسیم در گروه سنی تا پن سال و بالای 11 سال کاهش معنادار داشدت 16 % و کمترین درگیری در مفصل / فشارخون افزایش معنادار داشت. در این مطالعه بیشترین درگیری مفصل در زانو ۳ ۳6 % بهبودی داشتهاند. / ۳% بود که در نهایت بهطور معناداری در پاسخ به درمان ۳ / گردن با 4 نتيجهگيري: با توجه به در دسترس بودن، بهتر شدن عملکرد بیمار و کاهش علایم بالینی، این روش درمدا نی توص دیه میشود. هرچند نیاز به مطالعات بیشتر و مشاوره سایر متخصصین از جمله مشاوره قلد وعدروض ضدرور ی بده نظدر میرسد. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Tehran University Medical Journal is the property of Tehran University of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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