ASSOCIATIONS OF SERUM HIGH-SENSITIVITY C-REACTIVE PROTEIN AND PREALBUMIN WITH CORONARY VESSELS STENOSIS DETERMINED BY CORONARY ANGIOGRAPHY AND HEART FAILURE IN PATIENTS WITH MYOCARDIAL INFARCTION. (English)

POVEZANOST SERUMSKOG VISOKOOSETLJIVOG C-REAKTIVNOG PROTEINA I PREALBUMINA SA STENOZOM KORONARNIH SUDOVA UTVR\ENOM KORONAROGRAFIJOM I SRČANOM INSUFICIJENCIJOM KOD PACIJENATA SA INFARKTOM MIOKARDA. (Bosnian)

Background: To explore the associations of serum highsensitivity C-reactive protein (hs-CRP) and prealbumin (PAB) with the number of diseased coronary vessels, degree of stenosis and heart failure in patients with myocardial infarction (MI). Methods: A total of 39 MI patients treated in the Cardiology were selected as the observation group, and another 41 patients with normal results of coronary angiography during the same period were selected as the control group. The general data of patients were recorded in detail, the content of serum hs-CRP and PAB in the peripheral blood was detected, and the number of diseased coronary vessels and the degree of stenosis were detected via coronary angiography. Results: Compared with those in control group, the blood pressure and heart rate significantly rose, the content of indexes related to the severity of MI were significantly increased, the content of hs-CRP was significantly increased, and the content of PAB was significantly decreased in observation group. Hs-CRP was positively correlated with the number of diseased coronary vessels, degree of stenosis and heart failure in patients, but PAB was negatively correlated with the above factors. The survival rate of MI patients with high content of hs-CRP was obviously lower than that of patients with low content of hsCRP. Conclusions: Serum hs-CRP and PAB are closely associated with the number of diseased coronary vessels, degree of stenosis and heart failure in MI patients. [ABSTRACT FROM AUTHOR]

Uvod: Cilj je bio da se istraži povezanost serumskog visoko- osetljivog C-reaktivnog proteina (hs-CRP) i prealbumina (PAB) sa brojem obolelih koronarnih sudova, stepenom stenoze i srčanom insuficijencijom kod pacijenata sa infark- tom miokarda (MI). Metode: Za posmatračku grupu izabrano je ukupno 39 pacijenata sa IM lečenim kardiološki, a za kontrolnu grupu je izabran još 41 pacijent sa normalnim rezultatima koronarne angiografije u istom periodu. Detaljno su evi- dentirani opšti podaci pacijenata, detektovan je sadržaj serumskog hs-CRP i PAB u perifernoj krvi, a koronarogra- fijom je utvrđen broj obolelih koronarnih sudova i stepen stenoze. Rezultati: U poređenju sa onima u kontrolnoj grupi, zna- čajno su porasli krvni pritisak i puls, značajno je povećan sadržaj indeksa koji se odnose na težinu IM, značajno povećan sadržaj hs-CRP a značajno smanjen sadržaj PAB u posmatračkoj grupi. hs-CRP je bio u pozitivnoj korelaciji sa brojem obolelih koronarnih sudova, stepenom stenoze i srčanom insuficijencijom kod pacijenata, ali je PAB bio u negativnoj korelaciji sa navedenim faktorima. Stopa preživ- ljavanja pacijenata sa IM sa visokim sadržajem hs-CRP bila je očigledno niža nego kod pacijenata sa niskim sadržajem hs-CRP. Zaključak: Serumski hs-CRP i PAB su usko povezani sa brojem obolelih koronarnih sudova, stepenom stenoze i srčanom insuficijencijom kod pacijenata sa IM. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Medical Biochemistry is the property of Society of Medical Biochemists of Serbia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)