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McClellanville Library
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Phone: (843) 887-3699
Folly Beach Library
9 a.m. - 2 p.m.
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Miss Jane's Building (Edisto Library Temporary Location)
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Main Library
Closed (2024 Early Election)
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West Ashley Library
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St. Paul's/Hollywood Library
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Mt. Pleasant Library
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Dorchester Road Library
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Wando Mount Pleasant Library
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Emerging Preclinical Applications of Humanized Mouse Models in the Discovery and Validation of Novel Immunotherapeutics and Their Mechanisms of Action for Improved Cancer Treatment.
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- Author(s): Karnik, Isha; Her, Zhisheng; Neo, Shu Hui; Liu, Wai Nam; Chen, Qingfeng
- Source:
Pharmaceutics; Jun2023, Vol. 15 Issue 6, p1600, 29p- Subject Terms:
- Source:
- Additional Information
- Abstract: Cancer therapeutics have undergone immense research over the past decade. While chemotherapies remain the mainstay treatments for many cancers, the advent of new molecular techniques has opened doors for more targeted modalities towards cancer cells. Although immune checkpoint inhibitors (ICIs) have demonstrated therapeutic efficacy in treating cancer, adverse side effects related to excessive inflammation are often reported. There is a lack of clinically relevant animal models to probe the human immune response towards ICI-based interventions. Humanized mouse models have emerged as valuable tools for pre-clinical research to evaluate the efficacy and safety of immunotherapy. This review focuses on the establishment of humanized mouse models, highlighting the challenges and recent advances in these models for targeted drug discovery and the validation of therapeutic strategies in cancer treatment. Furthermore, the potential of these models in the process of uncovering novel disease mechanisms is discussed. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Pharmaceutics is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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