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[Therapeutic drug monitoring: A pharmacotherapeutic tool in psychiatry].
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- Author(s): Stephan PL;Stephan PL; Etzensberger M; Jaquenoud Sirot E
- Source:
Praxis [Praxis (Bern 1994)] 2006 Apr 26; Vol. 95 (17), pp. 671-8.- Publication Type:
Case Reports; English Abstract; Journal Article- Language:
German - Source:
- Additional Information
- Transliterated Title: Arzneimittelspiegel als pharmakotherapeutisches Werkzeug bei der Behandlung mit Psychopharmaka.
- Source: Publisher: Aerzteverlag medinfo AG Country of Publication: Switzerland NLM ID: 101468093 Publication Model: Print Cited Medium: Print ISSN: 1661-8157 (Print) Linking ISSN: 16618157 NLM ISO Abbreviation: Praxis (Bern 1994) Subsets: MEDLINE
- Publication Information: Publication: 2023- : Erlenbach : Aerzteverlag medinfo AG
Original Publication: Bern : Hallwag - Subject Terms: Drug Monitoring*; Mental Disorders/*blood ; Psychotropic Drugs/*pharmacokinetics; Adverse Drug Reaction Reporting Systems ; Antidepressive Agents, Tricyclic/administration & dosage ; Antidepressive Agents, Tricyclic/adverse effects ; Antidepressive Agents, Tricyclic/pharmacokinetics ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/pharmacokinetics ; Biological Availability ; Clomipramine/administration & dosage ; Clomipramine/adverse effects ; Clomipramine/pharmacokinetics ; Cytochrome P-450 CYP2D6/genetics ; Delusions/blood ; Delusions/drug therapy ; Depressive Disorder, Major/blood ; Depressive Disorder, Major/drug therapy ; Dibenzothiazepines/administration & dosage ; Dibenzothiazepines/adverse effects ; Dibenzothiazepines/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Interactions ; Drug Therapy, Combination ; Female ; Genotype ; Humans ; Male ; Mental Disorders/drug therapy ; Metabolic Clearance Rate/physiology ; Middle Aged ; Pharmacogenetics ; Psychotropic Drugs/administration & dosage ; Psychotropic Drugs/adverse effects ; Quetiapine Fumarate
- Abstract: Therapeutic drug monitoring (TDM) is used increasingly for managing psychiatric outpatients, where the preanalytic error risk is high. Blood samples must be collected under steady-state conditions immediately before ingestion of the morning dose or before the next injection. In order to interpret the plasma levels accurately, age, gender, ethnicity, compliance, drug dosage, renal and hepatic function and comedication incl. smoking habits and diet (esp. caffeine intake and consumption of grapefruit juice) have to be taken into account. If in doubt, aberrant plasma levels should be confirmed by a second control under optimized conditions. Pharmacogenetic testing enables the identification of abnormal metabolizers. TDM and pharmacogenetic tests are useful tools to improve pharmacotherapy by preventing dose-dependent adverse drug events, optimizing dosage during long-term treatment and identifying ultrarapid metabolizers and malcompliance.
- Accession Number: 0 (Antidepressive Agents, Tricyclic)
0 (Antipsychotic Agents)
0 (Dibenzothiazepines)
0 (Psychotropic Drugs)
2S3PL1B6UJ (Quetiapine Fumarate)
EC 1.14.14.1 (Cytochrome P-450 CYP2D6)
NUV44L116D (Clomipramine) - Publication Date: Date Created: 20060512 Date Completed: 20060802 Latest Revision: 20151119
- Publication Date: 20231215
- Accession Number: 10.1024/0369-8394.95.17.671
- Accession Number: 16686323
- Transliterated Title:
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