恶性肿瘤与骨密度因果关系的双向两样本 孟德尔随机化研究. (Chinese)

The causal relationship between cancer and bone mineral density: a bi - directional two - sample Mendelian randomization analysis. (English)

Objective To investigate the causal relationship be;twe;e;n malignancy and osteoporosis using bi - directional two - sample Mendelian randomization. Methods A dataset of 20 malignancies (prostate cancer, lymphatic and hematopoietic organ cancer, bladder e:ane;cr, brain eranccr, breast cancer, lung and bronchus e;ane:e;r, cervical e-ancer, colon cancer, kidney cancer, laryngerd e;ane;e;r, liver and intrahepatie; bile duct e;ane:e;r, esophageal cancer, ovarian cancer, pancreatic e:ane;cr, rectal cancer, skin cancer, small intestine cancer, gastric cancer, testicular cancer, thyroid cancer) was obtained from the Finngen database, and a dataset of whole - body bone mineral density (TB - BMD) was obtained from the GEFOS database;. The inverse variance; weighting me;thoel, weighted me;elian me;thoel anel MR - Egger meithoel were; uscel to assess the; bi - eli reertional causal relationship between 20 malignancies anel oste;oporosis risk. The; Cochran Q test, MR - Egger regression me;the)d, anel Leave; - one; - emt were; alse) uscel te> evaluate; the; stability anel reliability erf the; results. Results In terms erf e;ausality between breast anel laryngeal cancers anel TB -BMD, statistically significant e;ausality was observer!, anel the; remaining 18 malignancies hael no signifierant causal association with TB - BMD. Breast cancer may decrease; TB - BMD (/? = -0. 036, 95% C/; -0. 056 -- 0. 015, P = 0. 001) anel laryngeal cancer may increase; TB - BMD (/? = 0. 011, 95% Cl-, 0. 002 ~0. 021, P =0. 022), with statistically signifierant results Cochran Q te;st, MR - Egger regression, anel Le;ave; - one; - out all suggest the; stability anel reliability erf the; results erf this study. Conclusion Breast cancer may reduce; TB - BMD levels anel laryngeal e;anccr may increase; TB - BMD le;ve;ls. In clinical practice, breast cancer patients pay attention to bone; mineral density screening anel timely intervention for osteoporosis. [ABSTRACT FROM AUTHOR]

目的　运用双向两样本孟德尔随机化的方法ꎬ探讨恶性肿瘤和骨质疏松之间的因果关系ꎮ 方法　从Ｆｉｎｎｇｅｎ 数 据库获取２０ 种恶性肿瘤(前列腺癌、淋巴和造血器官癌、膀胱癌、脑癌、乳腺癌、肺和支气管癌、宫颈癌、结肠癌、肾癌、 喉癌、肝和肝内胆管癌、食管癌、卵巢癌、胰腺癌、直肠癌、皮肤癌、小肠癌、胃癌、睾丸癌、甲状腺癌)数据集ꎬ从ＧＥＦＯＳ 数据库获取全身骨密度(ＴＢ － ＢＭＤ)数据集ꎮ 运用逆方差加权法、加权中位数法和ＭＲ － Ｅｇｇｅｒ 法等评估２０ 种恶性肿 瘤与ＴＢ － ＢＭＤ 的双向因果关系ꎮ 采用Ｃｏｃｈｒａｎ Ｑ 检验、ＭＲ － Ｅｇｇｅｒ 回归法和Ｌｅａｖｅ － ｏｎｅ － ｏｕｔ 法评价研究结果稳定性 和可靠性ꎮ 结果　在乳腺癌、喉癌与ＴＢ － ＢＭＤ 的因果关系方面ꎬ观察到具有统计学意义的因果关系ꎬ其余１８ 种恶性 肿瘤与ＴＢ － ＢＭＤ 无显著因果关联ꎮ 乳腺癌可能降低ＴＢ － ＢＭＤ(β ＝ － ０􀆰 ０３６ꎬ９５％ ＣＩ: － ０􀆰 ０５６ ~ － ０􀆰 ０１５ꎬＰ ＝ ０􀆰 ００１)ꎬ 喉癌可能增加ＴＢ － ＢＭＤ(β ＝０􀆰 ０１１ꎬ９５％ＣＩ:０􀆰 ００２ ~０􀆰 ０２１ꎬ Ｐ ＝０􀆰 ０２２)ꎬ结果具有统计学意义ꎮ 加权中位数法和ＭＲ － Ｅｇｇｅｒ 法与逆方差加权法关联方向一致ꎮ Ｃｏｃｈｒａｎ Ｑ 检验、ＭＲ － Ｅｇｇｅｒ 回归和Ｌｅａｖｅ － ｏｎｅ － ｏｕｔ 法均提示本研究结果具 有稳定性和可靠性ꎮ 结论　乳腺癌可能降低ＴＢ － ＢＭＤ 水平ꎬ喉癌可能增加ＴＢ － ＢＭＤ 水平ꎮ 在临床实践中ꎬ乳腺癌患 者重视骨密度筛查ꎬ及时干预骨质疏松ꎮ. [ABSTRACT FROM AUTHOR]

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