Association of INSIG2 polymorphism with overweight and LDL in children.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Polymorphism, Single Nucleotide*; Dyslipidemias/*genetics ; Intracellular Signaling Peptides and Proteins/*genetics ; Membrane Proteins/*genetics ; Overweight/*genetics ; White People/*genetics; Adolescent ; Body Mass Index ; Child ; Dyslipidemias/ethnology ; Female ; Genetic Association Studies ; Humans ; Lipoproteins, LDL/metabolism ; Male ; Overweight/ethnology ; Students ; United States/ethnology
    • Abstract:
      Background: Dyslipidemia and overweight are common issues in children. Identifying genetic markers of risk could lead to targeted interventions. A polymorphism of SNP rs7566605 near insulin-induced gene 2 (INSIG2) has been identified as a strong candidate gene for obesity, through its feedback control of lipid synthesis.
      Objective: To identify polymorphisms in INSIG2 which are associated with overweight (BMI ≥ 85% for age) and dyslipidemia in children.
      Hypothesis: The C allele of rs7566605 would be significantly associated with BMI and LDL.
      Design/methods: We genotyped 15 SNPs in/near INSIG2 in 1,058 healthy children (53% non-Hispanic white (NHW), 37% overweight) participating in a school based study. Genotype was compared with BMI and lipid markers, adjusting for age, gender, and puberty.
      Results: We found a significant association between the SNP rs12464355 and LDL in NHW children, p < 0.001. The G allele is protective (lower LDL). A different SNP was associated with overweight in NHW: rs17047757. SNP rs7566605 was not associated with overweight or lipid levels.
      Conclusions: We identified novel genetic associations between INSIG2 and both overweight and LDL in NHW children. Polymorphisms in INSIG2 may be important in the development of obesity through its effects on lipid regulation.
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    • Grant Information:
      P30 DK078392 United States DK NIDDK NIH HHS; 1UL1RR026314-01 United States RR NCRR NIH HHS; DK59183 United States DK NIDDK NIH HHS; UL1 RR026314 United States RR NCRR NIH HHS; R01 DK059183 United States DK NIDDK NIH HHS
    • Accession Number:
      0 (INSIG2 protein, human)
      0 (Intracellular Signaling Peptides and Proteins)
      0 (Lipoproteins, LDL)
      0 (Membrane Proteins)
    • Publication Date:
      Date Created: 20150122 Date Completed: 20160104 Latest Revision: 20221207
    • Publication Date:
      20231215
    • Accession Number:
      PMC4301876
    • Accession Number:
      10.1371/journal.pone.0116340
    • Accession Number:
      25607990