Immune Response to Dengue and Zika.

Publisher: Annual Reviews Inc Country of Publication: United States NLM ID: 8309206 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-3278 (Electronic) Linking ISSN: 07320582 NLM ISO Abbreviation: Annu Rev Immunol

Original Publication: Palo Alto, Calif. : Annual Reviews Inc., c1983-

Dengue/*immunology ; Dengue Virus/*physiology ; Host-Pathogen Interactions/*immunology ; Zika Virus/*physiology ; Zika Virus Infection/*immunology; Adaptive Immunity ; Animals ; Dengue/metabolism ; Dengue/prevention & control ; Dengue/virology ; Humans ; Immunity, Innate ; Interferon Type I/metabolism ; Viral Tropism ; Viral Vaccines/immunology ; Zika Virus Infection/metabolism ; Zika Virus Infection/prevention & control ; Zika Virus Infection/virology

Flaviviruses such as dengue (DENV), yellow fever (YFV), West Nile (WNV), and Zika (ZIKV) are human pathogens of global significance. In particular, DENV causes the most prevalent mosquito-borne viral diseases in humans, and ZIKV emerged from obscurity into the spotlight in 2016 as the etiologic agent of congenital Zika syndrome. Owing to the recent emergence of ZIKV as a global pandemic threat, the roles of the immune system during ZIKV infections are as yet unclear. In contrast, decades of DENV research implicate a dual role for the immune system in protection against and pathogenesis of DENV infection. As DENV and ZIKV are closely related, knowledge based on DENV studies has been used to prioritize investigation of ZIKV immunity and pathogenesis, and to accelerate ZIKV diagnostic, therapeutic, and vaccine design. This review discusses the following topics related to innate and adaptive immune responses to DENV and ZIKV: the interferon system as the key mechanism of host defense and viral target for immune evasion, antibody-mediated protection versus antibody-dependent enhancement, and T cell-mediated protection versus original T cell antigenic sin. Understanding the mechanisms that regulate the balance between immune-mediated protection and pathogenesis during DENV and ZIKV infections is critical toward development of safe and effective DENV and ZIKV therapeutics and vaccines.

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R01 AI116813 United States AI NIAID NIH HHS; R21 AI127988 United States AI NIAID NIH HHS; R21 NS100477 United States NS NINDS NIH HHS

Keywords: Zika; adaptive immunity; dengue; innate immunity; vaccine

0 (Interferon Type I)
0 (Viral Vaccines)

Date Created: 20180119 Date Completed: 20190807 Latest Revision: 20190807

20240513

PMC5910217

10.1146/annurev-immunol-042617-053142

29345964