Kojic acid applications in cosmetic and pharmaceutical preparations.

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  • Author(s): Saeedi M;Saeedi M; Eslamifar M; Eslamifar M; Khezri K; Khezri K
  • Source:
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2019 Feb; Vol. 110, pp. 582-593. Date of Electronic Publication: 2018 Dec 08.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
    • Publication Information:
      Publication: Paris : Editions Scientifiques Elsevier
      Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
    • Subject Terms:
      Antioxidants/*pharmacology ; Cosmetics/*pharmacology ; Hyperpigmentation/*drug therapy ; Melanins/*antagonists & inhibitors ; Pyrones/*pharmacology ; Skin Pigmentation/*drug effects; Animals ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Antioxidants/therapeutic use ; Cosmetics/therapeutic use ; Free Radical Scavengers/pharmacology ; Free Radical Scavengers/therapeutic use ; Humans ; Hyperpigmentation/metabolism ; Melanins/metabolism ; Pyrones/therapeutic use ; Skin Pigmentation/physiology
    • Abstract:
      Skin color disorders can be caused by various factors, such as excessive exposure to sunlight, aging and hormonal imbalance during pregnancy, or taking some medications. Kojic acid (KA) is a natural metabolite produced by fungi that has the ability to inhibit tyrosinase activity in synthesis of melanin. The major applications of KA and its derivatives in medicine are based on their biocompatibility, antimicrobial and antiviral, antitumor, antidiabetic, anticancer, anti-speck, anti-parasitic, and pesticidal and insecticidal properties. In addition, KA and its derivatives are used as anti-oxidant, anti-proliferative, anti-inflammatory, radio protective and skin-lightening agent in skin creams, lotions, soaps, and dental care products. KA has the ability to act as a UV protector, suppressor of hyperpigmentation in human and restrainer of melanin formation, due to its tyrosinase inhibitory activity. Also, KA could be developed as a chemo sensitizer to enhance efficacy of commercial antifungal drugs or fungicides. In general, KA and its derivatives have wide applications in cosmetics and pharmaceutical industries.
      (Copyright © 2018 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
    • Contributed Indexing:
      Keywords: Cosmetic; Health brightening products; Hyperpigmentation; Kojic acid; Melanin
    • Accession Number:
      0 (Antifungal Agents)
      0 (Antioxidants)
      0 (Cosmetics)
      0 (Free Radical Scavengers)
      0 (Melanins)
      0 (Pyrones)
      6K23F1TT52 (kojic acid)
    • Publication Date:
      Date Created: 20181212 Date Completed: 20190422 Latest Revision: 20190422
    • Publication Date:
      20240513
    • Accession Number:
      10.1016/j.biopha.2018.12.006
    • Accession Number:
      30537675