An Architecture for Translational Cancer Research As Exemplified by the German Cancer Consortium.

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  • Additional Information
    • Source:
      Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101708809 Publication Model: Print Cited Medium: Internet ISSN: 2473-4276 (Electronic) Linking ISSN: 24734276 NLM ISO Abbreviation: JCO Clin Cancer Inform Subsets: MEDLINE
    • Publication Information:
      Original Publication: Alexandria, VA : American Society of Clinical Oncology, [2017]-
    • Subject Terms:
      Neoplasms*; Database Management Systems/*organization & administration ; Medical Informatics/*methods; Computer Security ; Germany ; Humans ; Information Dissemination ; Information Storage and Retrieval ; Medical Informatics/organization & administration ; Systematized Nomenclature of Medicine ; Translational Research, Biomedical
    • Abstract:
      Networking of medical institutions by means of a capable data infrastructure has the potential to open up vast amounts of routine data to translational cancer research. However, the secondary use of information collected independently in several institutions is a challenging task of data integration. In this review, we discuss the requirements and common challenges involved in the establishment of such a platform. We present methods and tools from the field of medical informatics as solutions to semantic and technical heterogeneity, questions of data protection and record linkage, as well as issues of trust and data ownership. We also describe the architecture of an existing cancer research network as an exemplary application of these methods.
    • Publication Date:
      Date Created: 20190118 Date Completed: 20191004 Latest Revision: 20211204
    • Publication Date:
      20240513
    • Accession Number:
      10.1200/CCI.17.00062
    • Accession Number:
      30652543