Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient.

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  • Author(s): Baffoe-Bonnie A; Houpt ER; Turner L; Dodge D; Heysell SK
  • Source:
    Emerging infectious diseases [Emerg Infect Dis] 2019 Nov; Vol. 25 (11), pp. 2120-2121. Date of Electronic Publication: 2019 Nov 17.
  • Publication Type:
    Case Reports; Letter
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
    • Subject Terms:
      Drug Resistance, Multiple, Bacterial*/drug effects ; Microbial Sensitivity Tests*; Antitubercular Agents/*pharmacology ; Mycobacterium tuberculosis/*drug effects ; Tuberculosis, Multidrug-Resistant/*diagnosis ; Tuberculosis, Multidrug-Resistant/*microbiology; Adult ; Antitubercular Agents/therapeutic use ; Bacterial Typing Techniques ; Drug Therapy, Combination ; Genes, Bacterial ; Humans ; Male ; Treatment Outcome ; Tuberculosis, Multidrug-Resistant/drug therapy
    • Abstract:
      A patient who had initial infection with mixed strains of drug-susceptible and multidrug-resistant tuberculosis was presumed to have acquired drug resistance before confirmation that sequential strains were genotypically distinct. Transmitted infection with mixed strains is likely underappreciated; identifying these infections requires spoligotyping and whole-genome sequencing.
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    • Contributed Indexing:
      Keywords: Mycobacterium tuberculosis; bacteria; drug resistance; heteroresistance; spoligotyping; tuberculosis and other mycobacteria; whole genome sequencing
    • Accession Number:
      0 (Antitubercular Agents)
    • Publication Date:
      Date Created: 20190828 Date Completed: 20200406 Latest Revision: 20200408
    • Publication Date:
      20240513
    • Accession Number:
      PMC6810186
    • Accession Number:
      10.3201/eid2511.180638
    • Accession Number:
      31454310